INT121944

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.49

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oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11) nucleus (Nr1i2)
DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 2 100.00 Very High Very High Very High
Necrosis 1 88.64 High High
Injury 1 85.52 High High
Hepatotoxicity 1 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation.
PXR Positive_regulation (inducing) of Gene_expression (expression) of CYP3A11 associated with toxicity and paracetamol
1) Confidence 0.78 Published 2004 Journal Toxicol. Sci. Section Abstract Doc Link 15456926 Disease Relevance 0.43 Pain Relevance 0.49

General Comments

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