INT121954

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 13.47
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cerebral white matter 2
heart 1
Mthfr (Rattus norvegicus)
Mthfr - C677T (4)
Pain Link Frequency Relevance Heat
Migraine 46 100.00 Very High Very High Very High
headache 9 99.68 Very High Very High Very High
Analgesic 1 99.56 Very High Very High Very High
Pain 5 92.76 High High
cva 7 89.96 High High
Inflammation 26 86.84 High High
Angina 8 83.12 Quite High
aspirin 1 78.00 Quite High
Crohn's disease 15 63.68 Quite High
Piles 15 54.56 Quite High
Disease Link Frequency Relevance Heat
Headache 39 100.00 Very High Very High Very High
Inflammatory Bowel Disease 75 99.90 Very High Very High Very High
Epilepsy 10 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 6 99.76 Very High Very High Very High
Migraine With Aura 12 99.64 Very High Very High Very High
Atherosclerosis 42 99.58 Very High Very High Very High
Disease 80 99.52 Very High Very High Very High
Diabetes Complications 4 99.44 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 4 98.08 Very High Very High Very High
Spontaneous Abortion 2 97.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.
MTHFR gene (C677T) Binding (Association) of associated with migraine
1) Confidence 0.44 Published 2009 Journal Cephalalgia Section Title Doc Link 17714520 Disease Relevance 0.43 Pain Relevance 0.42
We performed a meta-analysis of all published studies investigating the association between the MTHFR gene and migraine.
MTHFR gene Binding (association) of associated with migraine
2) Confidence 0.44 Published 2009 Journal Cephalalgia Section Abstract Doc Link 17714520 Disease Relevance 0.43 Pain Relevance 0.35
The MTHFR 677C>T SNP has previously been found to associate with various diabetic complications, including retinopathy [18-21], nephropathy [22-25], atherosclerosis [26], and coronary heart disease [27].
MTHFR Binding (associate) of in heart associated with coronary artery disease, atherosclerosis, diabetes complications, renal disease and ocular toxicity (including many sub-types)
3) Confidence 0.43 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 1.57 Pain Relevance 0
The methylenetetrahydrofolate reductase gene polymorphism (C677T) is associated with increased cardiovascular mortality in Hungary.
methylenetetrahydrofolate reductase Binding (associated) of
4) Confidence 0.35 Published 2004 Journal Int. J. Cardiol. Section Title Doc Link 15458711 Disease Relevance 0.51 Pain Relevance 0.13
This study provides evidence for an association of the MTHFR gene only in migraine with aura.
MTHFR gene Binding (association) of associated with migraine
5) Confidence 0.34 Published 2009 Journal Cephalalgia Section Abstract Doc Link 17714520 Disease Relevance 0.49 Pain Relevance 0.40
Finally, the discrepancies observed in previous studies on association between MTHFR and IBD may also correspond in part to differences in the proportion of cases with extensive colitis, as suggested by our observation that MTFHR is a predictor of pancolitis, at least in UC.
MTHFR Binding (association) of associated with colitis and inflammatory bowel disease
6) Confidence 0.30 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.78 Pain Relevance 0.06
Similarly, the association of MTHFR with other diseases than IBD seems to be neutral in South European countries, where the status of populations in folate is better than in North Europe, while some studies have showed association with MTR and MTRR in these countries [23,24].
MTHFR Binding (association) of associated with inflammatory bowel disease and disease
7) Confidence 0.30 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.72 Pain Relevance 0.04
Other studies, however, have found significant associations for homocysteine levels with increased atherosclerosis, yet no significant association for MTHFR genotype [9,35], raising the question of possible alternative causes for hyperhomocysteinemia and questioning the real importance of the MTHFR genotype.
MTHFR Neg (no) Binding (association) of associated with atherosclerosis and hyperhomocysteinemia
8) Confidence 0.28 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 0.71 Pain Relevance 0
Based on her miscarriage history, additional testing was undertaken during antenatal screening and the patient was found to have protein S deficiency and be heterozygous both for MTHFR and prothrombin G20210A genes.
MTHFR Binding (heterozygous) of associated with spontaneous abortion
9) Confidence 0.28 Published 2006 Journal J Cardiothorac Surg Section Body Doc Link PMC1624824 Disease Relevance 0.66 Pain Relevance 0.08
BACKGROUND: The MTHFR C677T genotype has been associated with increased risk of migraine, particularly of migraine with aura (MA) in selected clinical samples and with elevated homocysteine.
MTHFR (C677T) Binding (associated) of associated with migraine
10) Confidence 0.27 Published 2007 Journal Headache Section Abstract Doc Link 17300365 Disease Relevance 0.35 Pain Relevance 0.36
It would be therefore useful to revisit the studies on IBD and MTHFR that have been published in Europe by evaluating also the association with the other gene variants related with the remethylation pathway.
MTHFR Binding (association) of associated with inflammatory bowel disease
11) Confidence 0.23 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.71 Pain Relevance 0.05
It evidenced a significant association of MTR and MTHFR variants with the primary risk and the extent of the disease, respectively; 677TT and C677CT/1298AC genotypes of MTHFR were predictors of extensive colitis, while no association was found with the primary risk of UC.
MTHFR Binding (association) of associated with colitis and disease
12) Confidence 0.22 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.46 Pain Relevance 0.03
Ethnic and geographical variations in the distribution and phenotypic influence of MTHFR variants may explain, at least in part, discrepancies between case control studies on the association between MTHFR polymorphism and IBD [18,19].
MTHFR Binding (association) of associated with inflammatory bowel disease
13) Confidence 0.22 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 1.18 Pain Relevance 0.07
There were no differences in the genotype distributions of the previously migraine-associated SNPs C677T (MTHFR) and G2014A (ESR1) between cases and controls (P-values 0.83 and 0.55, respectively).
MTHFR (C677T) Binding (migraine-associated) of associated with migraine
14) Confidence 0.16 Published 2006 Journal Cephalalgia Section Abstract Doc Link 17116097 Disease Relevance 0.61 Pain Relevance 0.50
Angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms are linked to endothelial dysfunction and to cerebral white matter lesions.
methylenetetrahydrofolate reductase Binding (linked) of in cerebral white matter
15) Confidence 0.14 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19298544 Disease Relevance 0.43 Pain Relevance 0.30
ACE DD was associated with higher headache frequency, and MTHFR TT was associated with MA.
MTHFR Binding (associated) of associated with epilepsy and headache
16) Confidence 0.14 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19298544 Disease Relevance 0.70 Pain Relevance 0.52
Angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms are linked to endothelial dysfunction and to cerebral white matter lesions.
MTHFR Binding (linked) of in cerebral white matter
17) Confidence 0.12 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19298544 Disease Relevance 0.43 Pain Relevance 0.30
Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity.
MTHFR (C677T) Binding (associated) of associated with analgesic
18) Confidence 0.05 Published 2008 Journal J. Thromb. Thrombolysis Section Title Doc Link 18360788 Disease Relevance 0.35 Pain Relevance 0.27
Nevertheless, we observed a strong interaction between TS and MTHFR mutated genotypes, which increased over 8-fold the risk for experiencing aura among migraineurs; MTHFD1 and MTHFR mutated genotypes also increased together the risk for migraine in general (OR = 3.08; 95% CI = 1.3-7.4).
MTHFR Binding (interaction) of associated with epilepsy and migraine
19) Confidence 0.02 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15953655 Disease Relevance 0.67 Pain Relevance 0.65
METHODS: A first genotype-migraine association study was conducted on 100 patients with migraine with aura (MA), 106 with migraine without aura (MO), and 105 subjects without migraine, which provided evidence in favor of association of the TT677 MTHFR genotype with increased risk of MA compared with both control subjects (OR, 2.48; 95% CI, 1.11 to 5.58) and patients with MO (OR, 2.21; 95% CI, 1.01 to 4.82).
TT677 MTHFR Binding (association) of
20) Confidence 0.02 Published 2007 Journal Stroke Section Body Doc Link 17962595 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox