INT121970

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.52
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
lung 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 99.36 Very High Very High Very High
cytokine 3 98.84 Very High Very High Very High
Spinal cord 4 98.56 Very High Very High Very High
spinal dorsal horn 1 98.44 Very High Very High Very High
Hippocampus 4 97.88 Very High Very High Very High
ASIC 3 93.56 High High
Hyperalgesia 6 90.36 High High
substance P 3 86.76 High High
TRP channel 1 79.76 Quite High
Pain 7 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 28 99.36 Very High Very High Very High
Aids-related Complex 71 97.76 Very High Very High Very High
Ganglion Cysts 3 96.04 Very High Very High Very High
Hyperalgesia 6 90.36 High High
Hypercalcemia 3 89.64 High High
Osteoporosis 3 89.00 High High
Alzheimer's Dementia 1 86.56 High High
Acute-phase Reaction 2 85.68 High High
Immune System Diseases 2 84.28 Quite High
Disease 11 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Negative_regulation (decreased) of Transcription (expression) of c-Fos
1) Confidence 0.42 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.47 Pain Relevance 0.96
Up-regulated mRNA and protein expression of c-fos and fosB was abolished by SB204741, AG1478, and by U0126, an inhibitor of ERK phosphorylation by MAP kinase/ERK kinase.


Negative_regulation (abolished) of Transcription (expression) of c-fos
2) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
The time-course study showed that c-fos mRNA level was maximal at 10 min and began to decrease 30 min after the Sub P injection in all tissues, and the Sub P-induced increase of the c-fos mRNA level was returned to the control level 1 h after the injection.
Negative_regulation (decrease) of Transcription (level) of c-fos mRNA
3) Confidence 0.41 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.35
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Negative_regulation (downregulator) of Transcription (transcriptional) of FOS in lung associated with inflammation, aids-related complex and cytokine
4) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.04 Pain Relevance 0.17

General Comments

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