INT121985

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 10.52
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
lymphocyte 1
SLEB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 74 99.08 Very High Very High Very High
Pain 12 90.08 High High
anakinra 1 87.12 High High
Multiple sclerosis 95 85.80 High High
antagonist 2 81.76 Quite High
cytokine 11 76.64 Quite High
Arthritis 7 64.12 Quite High
chemokine 8 45.60 Quite Low
endometriosis 5 17.52 Low Low
Crohn's disease 5 16.92 Low Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 515 100.00 Very High Very High Very High
Autoimmune Disease 103 99.98 Very High Very High Very High
Renal Disease 69 99.28 Very High Very High Very High
INFLAMMATION 108 99.08 Very High Very High Very High
Disease 131 97.84 Very High Very High Very High
Infection 13 97.44 Very High Very High Very High
Myositis 1 92.36 High High
Arthritis 10 90.92 High High
Myalgia 1 90.08 High High
Systemic Sclerosis 7 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The therapy was well tolerated and the only significant side effect was a transient drop in complement levels (C3 and C4) without clinical or laboratory signs of increased SLE activity in all three patients.
Positive_regulation (increased) of SLE associated with systemic lupus erythematosus
1) Confidence 0.29 Published 2004 Journal Lupus Section Abstract Doc Link 15462491 Disease Relevance 0.93 Pain Relevance 0.25
For instance, it remains to be established at which developmental stage of SLE PCs start to accumulate in peripheral blood.



Positive_regulation (developmental stage) of SLE in blood associated with systemic lupus erythematosus
2) Confidence 0.07 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.87 Pain Relevance 0
In support, we found that two newly diagnosed SLE patients admitted to our hospital due to an elevated disease activity had strongly elevated CD27++ PC numbers that persisted during their hospital stay.
Positive_regulation (diagnosed) of SLE associated with disease and systemic lupus erythematosus
3) Confidence 0.06 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.47 Pain Relevance 0
We are not aware of any human cases of pristane induced SLE, this study should encourage further research on autoimmune diseases and environmental exposures.
Positive_regulation (induced) of SLE associated with autoimmune disease and systemic lupus erythematosus
4) Confidence 0.05 Published 2007 Journal Environ Health Section Body Doc Link PMC1821321 Disease Relevance 1.34 Pain Relevance 0.03
In addition to the finding of a significant increase in the prevalence of SLE in the exposed neighborhood the lymphocyte testing of the exposed population's immune system shows significant abnormality compared with the controls.
Positive_regulation (increase) of SLE in lymphocyte associated with systemic lupus erythematosus
5) Confidence 0.05 Published 2007 Journal Environ Health Section Body Doc Link PMC1821321 Disease Relevance 0.78 Pain Relevance 0
It has been demonstrated that both pristane and mercury will induce a condition in mice that mimics clinical features and the autoantibody pattern characteristic of SLE in humans.
Positive_regulation (induce) of SLE associated with systemic lupus erythematosus
6) Confidence 0.04 Published 2007 Journal Environ Health Section Body Doc Link PMC1821321 Disease Relevance 1.44 Pain Relevance 0.03
The residents sought legal advice because they were concerned that there was a connection between the apparent residual oil field waste and the elevated SLE cluster in their neighborhood.
Positive_regulation (elevated) of SLE associated with systemic lupus erythematosus
7) Confidence 0.04 Published 2007 Journal Environ Health Section Body Doc Link PMC1821321 Disease Relevance 0.40 Pain Relevance 0
Although autoimmunity initiates SLE and subsequently LN, the molecular and cellular mechanisms that trigger this autoimmunity are not discussed here.
Positive_regulation (initiates) of SLE associated with autoimmune disease, renal disease and systemic lupus erythematosus
8) Confidence 0.03 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2877652 Disease Relevance 1.29 Pain Relevance 0.09
The hypothesis that environmental toxins may induce lupus is consistent with the known ability of certain medications to cause SLE [77-79].
Positive_regulation (cause) of SLE associated with systemic lupus erythematosus
9) Confidence 0.03 Published 2007 Journal Environ Health Section Body Doc Link PMC1821321 Disease Relevance 0.67 Pain Relevance 0
A total of 264 unrelated SLE patients were consecutively recruited at the Columbus Children's Hospital and Research Institute, OSU, and followed in the Ohio SLE Study.
Positive_regulation (followed) of SLE associated with systemic lupus erythematosus
10) Confidence 0.03 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 1.34 Pain Relevance 0.24

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