INT121986

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Context Info
Confidence 0.76
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.83
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
brain 2
hippocampus 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 70 100.00 Very High Very High Very High
opioid receptor 84 99.96 Very High Very High Very High
Hippocampus 14 99.46 Very High Very High Very High
Anterior cingulate cortex 18 99.14 Very High Very High Very High
Glutamate 14 99.08 Very High Very High Very High
Kinase C 39 98.88 Very High Very High Very High
Lasting pain 7 98.24 Very High Very High Very High
Physical dependence 6 96.20 Very High Very High Very High
Morphine 79 95.40 Very High Very High Very High
narcan 7 93.84 High High
Disease Link Frequency Relevance Heat
Pain 11 98.24 Very High Very High Very High
Drug Dependence 7 96.20 Very High Very High Very High
Repression 1 79.96 Quite High
Targeted Disruption 26 61.68 Quite High
Opiate Addiction 8 55.20 Quite High
Depression 31 50.00 Quite Low
Anxiety Disorder 24 50.00 Quite Low
Urological Neuroanatomy 19 30.08 Quite Low
Nociception 10 5.00 Very Low Very Low Very Low
Shock 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, it has been reported the regional difference of NMDARs in the ACC and hippocampus, such as NR2A/NR2B ratio, phosphorylated NR2A and NR2B [18] as well as regulations under chronic pain conditions [6].
Phosphorylation (phosphorylated) of NR2A in hippocampus associated with lasting pain, hippocampus and anterior cingulate cortex
1) Confidence 0.76 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.10 Pain Relevance 0.32
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Phosphorylation (phosphorylated) of NR2A in brain associated with glutamate, nmda receptor, narcan and withdrawal
2) Confidence 0.73 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.29 Pain Relevance 0.87
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Phosphorylation (phosphorylated) of receptor epsilon 1 subunit in brain associated with glutamate, nmda receptor, narcan and withdrawal
3) Confidence 0.64 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.29 Pain Relevance 0.87
We found no change in the phosphorylation of NMDA receptor subunits NR1, NR2A or NR2B in TgDREAM mice (Figure 5B).
Phosphorylation (phosphorylation) of NR2A associated with nmda receptor
4) Confidence 0.58 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.14 Pain Relevance 0.58
was recruited to the MOR, NR2A was phosphorylated and the presence of G?
Phosphorylation (phosphorylated) of NR2A associated with opioid receptor
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.07

General Comments

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