INT121987

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.73
Pain Relevance 8.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
brain 2
glial cells 1
external 1
urethra 1
dorsal horn 1
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 95 100.00 Very High Very High Very High
Glutamate 21 99.86 Very High Very High Very High
Cancer pain 17 99.72 Very High Very High Very High
Morphine 97 99.70 Very High Very High Very High
Central grey 78 98.56 Very High Very High Very High
Dorsal horn 7 98.52 Very High Very High Very High
Pain 33 98.04 Very High Very High Very High
Physical dependence 6 97.76 Very High Very High Very High
qutenza 1 97.76 Very High Very High Very High
Thermal hyperalgesia 9 94.60 High High
Disease Link Frequency Relevance Heat
Bone Cancer 41 99.62 Very High Very High Very High
Reperfusion Injury 2 98.60 Very High Very High Very High
Urological Neuroanatomy 96 98.56 Very High Very High Very High
Pain 41 98.04 Very High Very High Very High
Drug Dependence 7 97.76 Very High Very High Very High
Stress Incontinence 10 95.60 Very High Very High Very High
Low Back Pain 2 95.44 Very High Very High Very High
Hyperalgesia 18 94.60 High High
Nociception 23 85.60 High High
Injury 22 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.
Phosphorylation (phosphorylation) of NR1 in dorsal horn associated with pain, nmda receptor and dorsal horn
1) Confidence 0.80 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16413788 Disease Relevance 1.00 Pain Relevance 1.16
Morphine pretreatment significantly inhibited nPKCepsilon membrane translocation and phosphorylation of NR1 subunits of NMDA receptors during reperfusion injury.
Phosphorylation (phosphorylation) of NR1 associated with reperfusion injury, nmda receptor and morphine
2) Confidence 0.80 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.17 Pain Relevance 0.99
At designated periods, slices were preserved for immunoblot analysis to observe effects of morphine pretreatment on membrane translocation and total protein expression of nPKCepsilon and phosphorylation of NR1 subunits of NMDA receptors.
Phosphorylation (phosphorylation) of NR1 associated with nmda receptor and morphine
3) Confidence 0.80 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.15 Pain Relevance 0.98
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Phosphorylation (phosphorylated) of NR1 in brain associated with glutamate, nmda receptor, narcan and withdrawal
4) Confidence 0.64 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.29 Pain Relevance 0.87
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Phosphorylation (phosphorylated) of receptor zeta subunit in brain associated with glutamate, nmda receptor, narcan and withdrawal
5) Confidence 0.56 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.29 Pain Relevance 0.87
Again, administration of LNNA or naltrindole before morphine prevented the phosphorylation of NMDAR subunits and the activation of CaMKII as well (Fig. 4).
Phosphorylation (phosphorylation) of NMDAR associated with morphine
6) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.25
Different reports have shown that phosphorylation of the NMDAR NR1 subunit is associated with noxious stimulation demonstrated by capsaicin, carrageenan and formalin injection to rodents [37-39].
Phosphorylation (phosphorylation) of NMDAR NR1 subunit associated with qutenza
7) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.11 Pain Relevance 1.21
released from glial cells is reported to facilitate bone cancer pain by enhancing phosphorylation of NMDA receptor NR-1 subunit [33].
Phosphorylation (phosphorylation) of NMDA receptor NR-1 subunit in glial cells associated with cancer pain, nmda receptor and bone cancer
8) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.71 Pain Relevance 0.63
We found no change in the phosphorylation of NMDA receptor subunits NR1, NR2A or NR2B in TgDREAM mice (Figure 5B).
Phosphorylation (phosphorylation) of NR1 associated with nmda receptor
9) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.14 Pain Relevance 0.58
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Phosphorylation (phosphorylation) of glutamatergic N-methyl-d-aspartate receptor in external associated with stress incontinence and dorsal horn
10) Confidence 0.05 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Phosphorylation (phosphorylation) of glutamatergic N-methyl-d-aspartate receptor in urethra associated with stress incontinence and dorsal horn
11) Confidence 0.02 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17

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