INT122003

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.44
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 99.88 Very High Very High Very High
Prostatitis 33 98.48 Very High Very High Very High
aspirin 11 98.48 Very High Very High Very High
cINOD 7 94.56 High High
Dopamine 3 94.40 High High
Inflammation 81 91.68 High High
dexamethasone 3 88.12 High High
rheumatoid arthritis 3 81.28 Quite High
COX-2 inhibitor 2 80.80 Quite High
Osteoarthritis 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Prostatitis 33 98.48 Very High Very High Very High
Multiple Myeloma 7 97.52 Very High Very High Very High
Sprains And Strains 60 96.28 Very High Very High Very High
INFLAMMATION 86 94.16 High High
Apoptosis 9 94.16 High High
Hypercalcemia 2 91.44 High High
Squamous Cell Carcinoma 3 83.08 Quite High
Chronic Lymphoid Leukemia 1 78.56 Quite High
Cancer 10 76.56 Quite High
Osteoarthritis 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results were further confirmed by evaluating the drugs' ability to reduce nuclear NF-kappaB subunits, as well as the amount of phosphorylated IkappaBalpha in cytosolic fractions.
Phosphorylation (phosphorylated) of IkappaBalpha
1) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.64 Pain Relevance 0.46
IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.
Phosphorylation (phosphorylation) of IkappaBalpha
2) Confidence 0.57 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Phosphorylation (phosphorylation) of IkappaBalpha-ubiquitination
3) Confidence 0.56 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.99 Pain Relevance 0.35
IL33 rapidly induced the phosphorylation of MAPKs and IkappaBalpha, and enhanced the expression of inflammatory mediators (IL6, IL8, IP-10, Gro-alpha, Gro-beta and MCP-1) in IL4- or IFNgamma-pretreated cells.
Phosphorylation (phosphorylation) of IkappaBalpha
4) Confidence 0.55 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.05 Pain Relevance 0
Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.
Phosphorylation (phosphorylation) of IkappaBalpha
5) Confidence 0.51 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.34 Pain Relevance 0.22
SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.
Phosphorylation (phosphorylation) of IkappaB-alpha associated with multiple myeloma
6) Confidence 0.07 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.88 Pain Relevance 0.11
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Phosphorylation (dephosphorylation) of IkappaB-alpha associated with aspirin
7) Confidence 0.07 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64
We assumed that the application of oligonol would be helpful for treating nonbacterial CP by regulating antioxidatives, proinflammatory cytokines, and IKBa phosphorylation.
Phosphorylation (phosphorylation) of IKBa associated with cytokine
8) Confidence 0.04 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703763 Disease Relevance 0.60 Pain Relevance 0.48
-induced phosphorylation of the inhibitor of kappa B (I?
Phosphorylation (phosphorylation) of kappa B
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2667254 Disease Relevance 1.26 Pain Relevance 0.26

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