INT122004

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 94.56 High High
dexamethasone 3 90.52 High High
rheumatoid arthritis 3 81.28 Quite High
Inflammation 6 75.00 Quite High
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 7 97.52 Very High Very High Very High
INFLAMMATION 9 94.16 High High
Hypercalcemia 2 93.16 High High
Chronic Lymphoid Leukemia 1 80.28 Quite High
Rheumatoid Arthritis 3 75.00 Quite High
Necrosis 2 75.00 Quite High
Cancer 2 75.00 Quite High
Apoptosis 1 50.00 Quite Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of IkappaBalpha
1) Confidence 0.41 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0
These results were further confirmed by evaluating the drugs' ability to reduce nuclear NF-kappaB subunits, as well as the amount of phosphorylated IkappaBalpha in cytosolic fractions.
Negative_regulation (reduce) of Phosphorylation (phosphorylated) of IkappaBalpha
2) Confidence 0.31 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.65 Pain Relevance 0.47
SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of IkappaB-alpha associated with multiple myeloma
3) Confidence 0.04 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.89 Pain Relevance 0.11

General Comments

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