INT122028

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.69

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

IFNA1 (Homo sapiens) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 2 100.00 Opioid 4 99.78 narcan 1 95.12 cytokine 1 94.08 Analgesic 2 86.36 mu opioid receptor 1 69.20

Disease Link Frequency Relevance Heat Fever 5 98.94

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is the first demonstration that fever induced by IFNalpha is mediated by opioid domain of IFNalpha interacting with opioid receptor.

IFNalpha Binding (interacting) of opioid receptor associated with opioid receptor, fever and opioid

1) Confidence 0.01 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15465601 Disease Relevance 0.41 Pain Relevance 0.69

General Comments

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