INT122029

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.68

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Oprd1 (Rattus norvegicus) IFNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 4 100.00 opioid receptor 2 100.00 mu opioid receptor 1 91.16 Analgesic 2 76.80 narcan 1 64.84 cytokine 1 55.04

Disease Link Frequency Relevance Heat Fever 5 99.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2.

opioid receptor Binding (interaction) of Positive_regulation (mediated) of interferon-alpha associated with opioid receptor, fever and opioid

1) Confidence 0.01 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 15465601 Disease Relevance 0.40 Pain Relevance 0.68

General Comments

This test has worked.