INT122037

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 93
Total Number 98
Disease Relevance 56.28
Pain Relevance 12.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 3
skeletal muscle 3
epithelial cells 2
body 2
plasma 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1245 100.00 Very High Very High Very High
Inflammation 867 100.00 Very High Very High Very High
rheumatoid arthritis 12 99.56 Very High Very High Very High
cINOD 285 99.40 Very High Very High Very High
Pain 32 99.24 Very High Very High Very High
Analgesic 17 98.92 Very High Very High Very High
aspirin 73 98.60 Very High Very High Very High
cytokine 243 98.28 Very High Very High Very High
metalloproteinase 27 97.80 Very High Very High Very High
Potency 54 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 1373 100.00 Very High Very High Very High
INFLAMMATION 1029 100.00 Very High Very High Very High
Obesity 979 100.00 Very High Very High Very High
Hyperplasia 51 100.00 Very High Very High Very High
Hypertrophy 33 100.00 Very High Very High Very High
Disease 396 99.98 Very High Very High Very High
Stress 428 99.92 Very High Very High Very High
Targeted Disruption 649 99.84 Very High Very High Very High
Sprains And Strains 171 99.60 Very High Very High Very High
Rheumatoid Arthritis 79 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we identify the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR-alpha) as the molecular target responsible for the anti-inflammatory properties of PEA.
Regulation (target) of PPAR-alpha associated with inflammation
1) Confidence 0.62 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15465922 Disease Relevance 0.59 Pain Relevance 0.33
of PPAR is altered and stabilized, and the PPAR-RXR heterodimer then recruits
Regulation (altered) of PPAR
2) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
It is well established that modulation of PPAR activity maintains cellular and whole-body
Regulation (modulation) of PPAR in body
3) Confidence 0.56 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 0.24 Pain Relevance 0.08
Here, we identify the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR-alpha) as the molecular target responsible for the anti-inflammatory properties of PEA.
Regulation (target) of nuclear receptor peroxisome proliferator-activated receptor-alpha associated with inflammation
4) Confidence 0.54 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15465922 Disease Relevance 0.59 Pain Relevance 0.33
The authors suggested that sex hormones regulate the sex difference in hepatic PPAR?
Regulation (regulate) of PPAR
5) Confidence 0.54 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.21 Pain Relevance 0.11
Epidermal regeneration has also been reported to be affected in PPAR?
Regulation (affected) of PPAR
6) Confidence 0.54 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.88 Pain Relevance 0.13
mechanism of the effect of the PGI2 on PPAR?
Regulation (effect) of PPAR
7) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.67 Pain Relevance 0
factors regulated PPAR?
Regulation (regulated) of PPAR
8) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.67 Pain Relevance 0.03
Intrinsic factors that may affect PPAR-mediated risks
Spec (may) Regulation (affect) of PPAR
9) Confidence 0.45 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.68 Pain Relevance 0.09
They suggested that some changes in gene expression were dependent on PPAR?
Regulation (dependent) of PPAR
10) Confidence 0.45 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.36 Pain Relevance 0
Interestingly, the phenotype of RIP140 knockout mice suggests a role for this corepressor in PPAR?
Regulation (role) of PPAR associated with targeted disruption
11) Confidence 0.45 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0
1.2 nM and >1000-fold selectivity over the other murine PPAR
Regulation (selectivity) of PPAR
12) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.12 Pain Relevance 0.40
Effect of PPAR agonists on serum chemistry
Regulation (Effect) of PPAR associated with agonist
13) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.60 Pain Relevance 0.22
Effect of PPAR agonists on body weight, body mass,
and food consumption
Regulation (Effect) of PPAR in body associated with body weight and agonist
14) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.54 Pain Relevance 0.14
ligands fibrates stimulate hepatic FA oxidation and thus reduce the levels of plasma triglycerides responsible for adipose cell hypertrophy and hyperplasia, PPAR?
Regulation (responsible) of PPAR in plasma associated with hypertrophy and hyperplasia
15) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.97 Pain Relevance 0
Based on my published results showing the fenofibrate functions on obesity during various conditions, this paper will focus on the differential regulation of PPAR?
Regulation (regulation) of PPAR associated with obesity
16) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.20 Pain Relevance 0
Similar to the results of Akiyama et al. [80], Yoon et al. [20] provided evidence that fenofibrate is involved in obesity, but not likely to have an effect on obesity mainly through PPAR?
Regulation (effect) of PPAR associated with obesity
17) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.01 Pain Relevance 0
However, important central regulatory proteins such as the obesity gene leptin or PPAR-?
Regulation (important) of PPAR associated with obesity
18) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.37 Pain Relevance 0
However, important central regulatory proteins such as the obesity gene leptin or PPAR-?
Regulation (regulatory) of PPAR associated with obesity
19) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.37 Pain Relevance 0
This paper focuses on the effects of PPAR agonists on metabolic functions with particular reference to AMPK activity modulation.

2.

Regulation (effects) of PPAR associated with agonist
20) Confidence 0.43 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.13 Pain Relevance 0.14

General Comments

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