INT122038

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 20.50
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 1
CAR 1
bone marrow 1
skin 1
body 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 99.92 Very High Very High Very High
agonist 391 99.76 Very High Very High Very High
aspirin 36 99.36 Very High Very High Very High
cINOD 152 98.76 Very High Very High Very High
Inflammation 524 97.72 Very High Very High Very High
chemokine 26 96.76 Very High Very High Very High
cytokine 108 95.68 Very High Very High Very High
Multiple sclerosis 80 95.32 Very High Very High Very High
COX-2 inhibitor 10 94.08 High High
Central nervous system 58 91.80 High High
Disease Link Frequency Relevance Heat
Obesity 389 100.00 Very High Very High Very High
Cancer 933 99.74 Very High Very High Very High
Breast Cancer 34 99.60 Very High Very High Very High
Apoptosis 313 99.50 Very High Very High Very High
Adhesions 46 98.24 Very High Very High Very High
Ductal Carcinoma 2 98.00 Very High Very High Very High
Colon Cancer 201 97.92 Very High Very High Very High
Body Weight 179 97.90 Very High Very High Very High
INFLAMMATION 585 97.72 Very High Very High Very High
Targeted Disruption 115 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
on body weight, WAT mass, and circulating lipid levels by E2 may be attributed, in part, to reductions in hepatic mRNA expression of PPAR?
Transcription (expression) of PPAR in body associated with body weight and obesity
1) Confidence 0.71 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.54 Pain Relevance 0
-null mice. mRNA levels for PPAR?
Transcription (levels) of PPAR
2) Confidence 0.70 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.39 Pain Relevance 0.03
and transcriptional activation of PPAR?
Transcription (transcriptional) of PPAR
3) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.41 Pain Relevance 0
According to Yoon et al. [20], fenofibrate elevated the transcriptional activation of PPAR?
Transcription (transcriptional) of PPAR
4) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.63 Pain Relevance 0
-deficient bone marrow cells overrides a potential tumor stimulatory contribution of PPAR?
Transcription (contribution) of PPAR in bone marrow associated with cancer
5) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.00 Pain Relevance 0.05
The dependence of PPARalpha- and CAR-regulated gene transcription on coactivator PBP but not on PRIP attests to the existence of coactivator selectivity in nuclear receptor function.
Transcription (transcription) of PPARalpha in CAR associated with addiction
6) Confidence 0.66 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.23 Pain Relevance 0.13
Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver.
Transcription (function) of PParalpha in liver
7) Confidence 0.66 Published 2007 Journal Gene Expr. Section Title Doc Link 17605299 Disease Relevance 0.26 Pain Relevance 0.05
dominant negative regulator of PPAR-mediated gene transcription [55, 65, 66].
Transcription (transcription) of PPAR-mediated
8) Confidence 0.64 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.09 Pain Relevance 0
the transcriptional activity of PPAR?
Transcription (activity) of PPAR
9) Confidence 0.64 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.92 Pain Relevance 0.33
transcriptional activity of PPAR?
Transcription (activity) of PPAR
10) Confidence 0.63 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 0.71 Pain Relevance 0.07
by a ligand, the PPAR:RXR dimer controls transcription via binding to the
Transcription (transcription) of PPAR
11) Confidence 0.63 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.12 Pain Relevance 0.03
On the other hand, to evaluate the contribution of PPAR?
Transcription (contribution) of PPAR
12) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.08 Pain Relevance 0
the transcriptional activity of PPAR?
Transcription (activity) of PPAR
13) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.92 Pain Relevance 0.33
transcriptional activity of PPAR?
Transcription (transcriptional) of PPAR
14) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 0.72 Pain Relevance 0.07
apoptosis in Jurkat cells was not mediated by PPAR?
Neg (not) Transcription (mediated) of PPAR associated with apoptosis
15) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 0.83 Pain Relevance 0.63
It has also been suggested that PPAR-?
Transcription (suggested) of PPAR
16) Confidence 0.61 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.41 Pain Relevance 0.25
-mediated gene transcription in PPAR?
Transcription (transcription) of PPAR
17) Confidence 0.60 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.92 Pain Relevance 0.26
In the absence of a specific ligand, PPAR?
Neg (absence) Transcription (absence) of PPAR
18) Confidence 0.60 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0 Pain Relevance 0
PEA selectively activates PPAR-alpha in vitro with an EC(50) value of 3.1 +/- 0.4 microM and induces the expression of PPAR-alpha mRNA when applied topically to mouse skin.
Transcription (expression) of PPAR-alpha in skin
19) Confidence 0.53 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15465922 Disease Relevance 0.61 Pain Relevance 0.37
PCNA mRNA expression and mRNA expression of the PPAR?
Transcription (expression) of PPAR
20) Confidence 0.52 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.21 Pain Relevance 0

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