INT122040

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.97
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
skin 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 214 95.48 Very High Very High Very High
antagonist 11 90.04 High High
cytokine 20 87.52 High High
Pain 5 86.60 High High
Analgesic 2 81.08 Quite High
agonist 86 80.88 Quite High
Inflammatory response 18 79.36 Quite High
Central nervous system 15 73.12 Quite High
Cannabinoid 92 57.36 Quite High
Multiple sclerosis 4 45.28 Quite Low
Disease Link Frequency Relevance Heat
Obesity 192 100.00 Very High Very High Very High
INFLAMMATION 235 95.48 Very High Very High Very High
Pressure And Volume Under Development 2 92.80 High High
Necrosis 2 89.32 High High
Cancer 170 88.96 High High
Apoptosis 24 87.28 High High
Targeted Disruption 51 86.88 High High
Pain 5 86.60 High High
Atherosclerotic Plaque 4 82.44 Quite High
Liver Cancer 34 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and transcriptional activation of PPAR?
Positive_regulation (activation) of Transcription (transcriptional) of PPAR
1) Confidence 0.50 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.41 Pain Relevance 0
According to Yoon et al. [20], fenofibrate elevated the transcriptional activation of PPAR?
Positive_regulation (activation) of Transcription (transcriptional) of PPAR
2) Confidence 0.50 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.63 Pain Relevance 0
in vitro and activate the transcriptional activity of PPAR?
Positive_regulation (activate) of Transcription (activity) of PPAR
3) Confidence 0.49 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.42 Pain Relevance 0.32
PEA selectively activates PPAR-alpha in vitro with an EC(50) value of 3.1 +/- 0.4 microM and induces the expression of PPAR-alpha mRNA when applied topically to mouse skin.
Positive_regulation (induces) of Transcription (expression) of PPAR-alpha in skin
4) Confidence 0.47 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15465922 Disease Relevance 0.61 Pain Relevance 0.37
by a ligand, the PPAR:RXR dimer controls transcription via binding to the
Positive_regulation (via) of Transcription (transcription) of PPAR
5) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.12 Pain Relevance 0.03
by a ligand, the PPAR:RXR dimer controls transcription via binding to the
Positive_regulation (by) of Transcription (transcription) of PPAR
6) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.12 Pain Relevance 0.03
-mediated gene transcription in PPAR?
Positive_regulation (mediated) of Transcription (transcription) of PPAR
7) Confidence 0.44 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.93 Pain Relevance 0.26
in vitro and activate the transcriptional activity of PPAR?
Positive_regulation (activate) of Transcription (activity) of PPAR
8) Confidence 0.35 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.42 Pain Relevance 0.32
activates the transcription of mitochondrial uncoupling protein-1 (UCP-1) in BAT through interactions with the nuclear hormone receptors PPAR?
Positive_regulation (activates) of Transcription (transcription) of PPAR associated with obesity
9) Confidence 0.29 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.32 Pain Relevance 0

General Comments

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