INT122041

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 308
Total Number 313
Disease Relevance 189.17
Pain Relevance 51.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 5
nucleus 2
hepatocytes 2
macrophages 1
plasma 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 821 100.00 Very High Very High Very High
fluoxetine 6 100.00 Very High Very High Very High
agonist 5392 99.98 Very High Very High Very High
Inflammation 5400 99.96 Very High Very High Very High
cytokine 1499 99.90 Very High Very High Very High
antagonist 527 99.88 Very High Very High Very High
Pain 163 99.84 Very High Very High Very High
qutenza 9 99.70 Very High Very High Very High
Inflammatory mediators 135 99.60 Very High Very High Very High
Analgesic 45 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 6557 100.00 Very High Very High Very High
Obesity 3358 100.00 Very High Very High Very High
Targeted Disruption 1399 100.00 Very High Very High Very High
Shock 1264 100.00 Very High Very High Very High
Spinal Cord Injury 416 100.00 Very High Very High Very High
Malignant Neoplastic Disease 120 100.00 Very High Very High Very High
Weight Gain 382 99.98 Very High Very High Very High
Melanoma 57 99.98 Very High Very High Very High
INFLAMMATION 6271 99.96 Very High Very High Very High
Metabolic Disorder 602 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Poole et al. (2001) have shown that after an agonist binds to the PPAR?
PPAR Binding (binds) of associated with agonist
1) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.35 Pain Relevance 0.36
These compounds also affect lipoprotein composition and reduce atherosclerotic plaque formation without the weight gain associated with PPAR?
PPAR Binding (associated) of in plaque associated with atherosclerotic plaque and weight gain
2) Confidence 0.48 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 1.14 Pain Relevance 0.31
activation by microgram-order perfluorooctanoate, a ligand of PPAR?
PPAR Binding (ligand) of
3) Confidence 0.47 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.41 Pain Relevance 0.07
is independent of the promoter context but appears to depend on a physical interaction between PPAR?
PPAR Binding (interaction) of
4) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.91 Pain Relevance 0.33
However, simultaneous ligand binding of PPAR?
PPAR Binding (binding) of
5) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.39 Pain Relevance 0.33
with the binding of PPAR to the peroxisome proliferator response element (PPRE)
PPAR Binding (binding) of
6) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.05 Pain Relevance 0
Ligand-unbound PPAR is associated with chaperon
PPAR Binding (associated) of
7) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
of PPAR is altered and stabilized, and the PPAR-RXR heterodimer then recruits
PPAR-RXR Binding (recruits) of
8) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
expression due to the stabilization of the binding of PPAR?
PPAR Binding (binding) of
9) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.06
on the ligand-dependent binding between PPAR and coactivators.
PPAR Binding (binding) of
10) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.17
assays are based on direct interaction between PPAR and their specific ligands,
PPAR Binding (interaction) of
11) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.16 Pain Relevance 0.30
acts as a supporting factor for strong DNA binding of PPAR.
PPAR Binding (binding) of
12) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.06 Pain Relevance 0.09
of ligands, PPAR is associated with corepressors.
PPAR Binding (associated) of
13) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.05 Pain Relevance 0
PPAR also heterodimerize
PPAR Binding (heterodimerize) of
14) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.31 Pain Relevance 0.06
nonsteroidal anti-inflammatory drug ibuprofen, which is also a ligand for PPAR?
PPAR Binding (ligand) of associated with inflammation and cinod
15) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.78 Pain Relevance 0.59
FABPs bind PPAR ligands within the cytoplasm, channel this cargo to the
PPAR Binding (bind) of
16) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.72 Pain Relevance 0.11
by a ligand, the PPAR:RXR dimer controls transcription via binding to the
PPAR Binding (binding) of
17) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.12 Pain Relevance 0.03
require high-affinity binding of PPAR ligand to engage transcription [7].
PPAR Binding (binding) of
18) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.36 Pain Relevance 0.14
Shureiqi et al. showed that 13-S-HODE bound to PPAR?
PPAR Binding (bound) of
19) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.93 Pain Relevance 0.07
induces apoptosis did not affect the DNA binding of PPAR?
PPAR Binding (binding) of associated with apoptosis
20) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 0.83 Pain Relevance 0.55

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