INT122060

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.06
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sorbs1) transport (Sorbs1) plasma membrane (Sorbs1)
cytoskeleton (Sorbs1) nucleus (Sorbs1) cytoplasm (Sorbs1)
Sorbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 104 100.00 Very High Very High Very High
Nerve growth factor 200 99.98 Very High Very High Very High
Calcitonin gene-related peptide 194 99.68 Very High Very High Very High
nociceptor 13 78.72 Quite High
Neuropeptide 22 50.00 Quite Low
Trigeminal ganglion neurons 2 50.00 Quite Low
trigeminal ganglion 118 20.16 Low Low
dorsal root ganglion 24 5.00 Very Low Very Low Very Low
Migraine 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 4 62.24 Quite High
Ganglion Cysts 146 50.00 Quite Low
Injury 46 5.00 Very Low Very Low Very Low
Nociception 16 5.00 Very Low Very Low Very Low
Hyperalgesia 14 5.00 Very Low Very Low Very Low
Headache 12 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAP stimulation induced a significant CGRP release, which, however, did not correlate with the temporal development of OA in STR/1N mice.
Positive_regulation (induced) of Positive_regulation (stimulation) of CAP
1) Confidence 0.34 Published 2004 Journal J. Rheumatol. Section Body Doc Link 15468368 Disease Relevance 0.06 Pain Relevance 0
In every case, GDNF and NGF (except 1 ng/ml NGF) supplementation significantly enhanced CAP-evoked CGRP release over the same concentration of BDNF (Fig 8A).
Neg (except) Positive_regulation (supplementation) of Positive_regulation (enhanced) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
2) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.43
Because treatment with either GDNF or NGF induced a large increase in 100 nM CAP-evoked CGRP release, we assessed the effect of supplementation with these growth factors on the receptor pharmacodynamics of this response compared with no growth factor supplementation.
Positive_regulation (induced) of Positive_regulation (increase) of CAP associated with qutenza, nerve growth factor and calcitonin gene-related peptide
3) Confidence 0.02 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.14

General Comments

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