INT122078

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Context Info
Confidence 0.76
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.25
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crygb) cytoplasm (Crygb)
Anatomy Link Frequency
brain 4
spinal cord 2
Crygb (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 31 100.00 Very High Very High Very High
Spinal cord 5 99.76 Very High Very High Very High
Morphine 4 99.56 Very High Very High Very High
opioid receptor 5 99.28 Very High Very High Very High
agonist 7 98.82 Very High Very High Very High
addiction 7 95.88 Very High Very High Very High
tolerance 7 95.28 Very High Very High Very High
Analgesic 1 94.88 High High
Opioid 8 94.64 High High
nMDA receptor 2 91.92 High High
Disease Link Frequency Relevance Heat
Infection 18 99.68 Very High Very High Very High
Gonorrhea 13 95.92 Very High Very High Very High
Anxiety Disorder 3 93.40 High High
Pain 4 89.68 High High
Targeted Disruption 5 88.72 High High
Stress 4 88.08 High High
Sprains And Strains 39 32.08 Quite Low
Neuroleptic Malignant Syndrome 9 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 6 5.00 Very Low Very Low Very Low
Chlamydia Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Nociceptin is the endogenous agonist of the opioid receptor-like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics.
Gene_expression (expressed) of NOP in spinal cord associated with orphanin, agonist, opioid receptor and spinal cord
1) Confidence 0.76 Published 2005 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 15954957 Disease Relevance 0.18 Pain Relevance 0.54
BACKGROUND: Nociceptin is the endogenous agonist of the opioid receptor-like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics.
Gene_expression (expressed) of NOP in spinal cord associated with orphanin, agonist, opioid receptor and spinal cord
2) Confidence 0.76 Published 2005 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 15954957 Disease Relevance 0.18 Pain Relevance 0.54
The antigenically variable neisserial opacity (Opa) proteins are expressed during infection and have a semivariable (SV) and highly conserved (4L) loop that could be targeted in a vaccine.
Gene_expression (expressed) of opacity associated with infection
3) Confidence 0.75 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779592 Disease Relevance 0.27 Pain Relevance 0
Chronic morphine-treatments increased NOP gene or epsilon1 subunit protein expression in the spinal cord or specific brain loci, respectively.
Gene_expression (expression) of NOP in brain associated with spinal cord and morphine
4) Confidence 0.50 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469049 Disease Relevance 0.09 Pain Relevance 1.86
BACKGROUND: Nociceptin is the endogenous agonist of the opioid receptor-like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics.
Gene_expression (expressed) of NOP in brain associated with orphanin, agonist, opioid receptor and spinal cord
5) Confidence 0.26 Published 2005 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 15954957 Disease Relevance 0.18 Pain Relevance 0.54
BACKGROUND: Nociceptin is the endogenous agonist of the opioid receptor-like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics.
Gene_expression (expressed) of NOP in brain associated with orphanin, agonist, opioid receptor and spinal cord
6) Confidence 0.26 Published 2005 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 15954957 Disease Relevance 0.18 Pain Relevance 0.54
Thus, the N/OFQ and NOP receptor are located in the central nervous systems in humans, primates, and rodents, and are involved in the integration of the emotional components in the brain; e.g., N/OFQ displays anxiolytic activity in the brain.
Gene_expression (located) of NOP receptor in brain associated with anxiety disorder
7) Confidence 0.10 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19125610 Disease Relevance 0.18 Pain Relevance 0.33

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