INT122096

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1) plasma membrane (HLA-B)
Anatomy Link Frequency
leukocyte 1
lower limbs 1
HLA-B (Homo sapiens)
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 100.00 Very High Very High Very High
psoriasis 2 100.00 Very High Very High Very High
backache 2 100.00 Very High Very High Very High
spondylitis 2 99.96 Very High Very High Very High
Arthritis 1 99.30 Very High Very High Very High
spinal inflammation 1 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Low Back Pain 5 100.00 Very High Very High Very High
INFLAMMATION 4 100.00 Very High Very High Very High
Psoriasis 2 100.00 Very High Very High Very High
Uveitis 2 100.00 Very High Very High Very High
Inflammatory Bowel Disease 2 100.00 Very High Very High Very High
Syndrome 1 100.00 Very High Very High Very High
Sacroiliitis 1 100.00 Very High Very High Very High
Seronegative Spondarthritis 1 99.30 Very High Very High Very High
Targeted Disruption 3 75.00 Quite High
Immunization 1 61.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goals were to create and establish units for the early management of patients with SpAs and to develop a communication system between general practitioners and rheumatologists for early referral of patients with suspected spondylitis, according to the following criteria: patients <45 years of age with >3 and <24 months of evolution of one of the three following syndromes: (i) inflammatory back pain, defined in the specific case of the project as back pain with at least two out of three from the following: insidious onset, morning stiffness >30 min and improvement with exercise; (ii) asymmetrical oligoarthritis of the lower limbs (at least one and maximum four big joints in the lower limbs affected asymmetrically); and (iii) other suspicious criteria as: rachialgia plus at least one of following: psoriasis; IBD; acute anterior uveitis; family history of SpA, psoriasis, IBD or anterior uveitis; Rx sacroiliitis; and HLA-B27 positivity.
HLA-B27 Binding (according) of SpA in lower limbs associated with psoriasis, sacroiliitis, spondylitis, syndrome, backache, inflammatory bowel disease, inflammation and uveitis
1) Confidence 0.04 Published 2011 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2999954 Disease Relevance 1.25 Pain Relevance 0.40
The pathology of ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies (SpA) is closely associated with the human leukocyte class I Ag HLA-B27.
HLA-B27 Binding (associated) of SpA in leukocyte associated with seronegative spondarthritis, spinal inflammation and arthritis
2) Confidence 0.03 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15470026 Disease Relevance 0.56 Pain Relevance 0.20

General Comments

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