INT1221

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2010
Negated 4
Speculated 10
Reported most in Abstract
Documents 65
Total Number 75
Disease Relevance 24.21
Pain Relevance 22.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
cranial 2
oocytes 2
superior 2
plasma 1
brain 1
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 56 100.00 Very High Very High Very High
alcohol 51 100.00 Very High Very High Very High
ketamine 33 100.00 Very High Very High Very High
isoflurane 30 100.00 Very High Very High Very High
Botox 26 100.00 Very High Very High Very High
anesthesia 15 100.00 Very High Very High Very High
cINOD 14 100.00 Very High Very High Very High
tramadol 12 100.00 Very High Very High Very High
Glutamate 12 100.00 Very High Very High Very High
antagonist 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gastric Motility Disorder 11 99.98 Very High Very High Very High
Syndrome 7 99.98 Very High Very High Very High
Bites And Stings 4 99.80 Very High Very High Very High
Neuropathic Pain 56 99.72 Very High Very High Very High
Pancreatitis 33 99.62 Very High Very High Very High
Pain 339 99.48 Very High Very High Very High
Alcohol Addiction 10 99.28 Very High Very High Very High
INFLAMMATION 39 99.06 Very High Very High Very High
Cancer 54 99.04 Very High Very High Very High
Osteogenesis Imperfecta 8 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of local and intravenous anesthetics on the activity of glutamate transporter type 2.
Regulation (Effects) of type associated with glutamate
1) Confidence 0.60 Published 2003 Journal Brain Res. Bull. Section Title Doc Link 13679253 Disease Relevance 0 Pain Relevance 0.78
IMPLICATIONS: We examined the effects of tramadol on 5-hydroxytryptamine type 2C receptor (5-HT(2C)R) expressed in Xenopus oocytes.
Spec (examined) Regulation (effects) of type in oocytes associated with tramadol
2) Confidence 0.60 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15105221 Disease Relevance 0.06 Pain Relevance 0.90
Osteogenesis imperfecta (OI) is a heterogeneous group of disorders principally affecting type I collagen.
Regulation (affecting) of type associated with osteogenesis imperfecta
3) Confidence 0.60 Published 2000 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11086652 Disease Relevance 0.69 Pain Relevance 0.09
Osteogenesis imperfecta is a heterogeneous group of inherited disorders chiefly affecting type I collagen, resulting in bone fragility responsible for a host of recurrent fractures.
Regulation (affecting) of type associated with osteogenesis imperfecta
4) Confidence 0.60 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 12482741 Disease Relevance 0.48 Pain Relevance 0.07
Gastroparesis affects both type 1 (insulin dependent) and type 2 (non- insulin dependent) forms of diabetes.
Regulation (affects) of type associated with diabetes mellitus and gastric motility disorder
5) Confidence 0.60 Published 2003 Journal Drugs Section Abstract Doc Link 12825960 Disease Relevance 1.82 Pain Relevance 0.23
The effects of NSAID on the amount of type 11 collagen and proteoglycan mRNA were consistent with those on collagen and proteoglycan biosynthesis.
Regulation (effects) of type associated with cinod
6) Confidence 0.60 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2810293 Disease Relevance 0 Pain Relevance 0.37
Adenylyl cyclase type II activity is regulated by two different mechanisms: implications for acute and chronic opioid exposure.
Regulation (regulated) of type associated with narcan and opioid
7) Confidence 0.60 Published 2006 Journal Neuropharmacology Section Title Doc Link 16545401 Disease Relevance 0.05 Pain Relevance 0.78
Certain metabolites of progesterone and deoxycorticosterone are established as potent and selective positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Regulation (modulators) of type associated with gaba
8) Confidence 0.44 Published 2003 Journal Prog. Neurobiol. Section Abstract Doc Link 14611869 Disease Relevance 0.18 Pain Relevance 0.21
The analysis of the allelic frequencies of whole families with trypsinogen mutations revealed that all subjects with the TNF-238A variant suffered from chronic pancreatitis, whereas all intrafamilial controls with wild-type TNF were unaffected.
Regulation (controls) of type
9) Confidence 0.44 Published 2003 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 14560157 Disease Relevance 0 Pain Relevance 0
Botox Cosmetic (Botox) is a formulation of the neuromuscular blocking agent botulinum toxin type A (BTX-A).
Regulation (formulation) of type associated with botox
10) Confidence 0.44 Published 2003 Journal Am J Clin Dermatol Section Abstract Doc Link 14507232 Disease Relevance 0.08 Pain Relevance 0.27
CONCLUSION: Botulinum toxin type A is effective in the treatment of foot pain associated with plantar fasciitis and increases the centre of pressure velocity during loading response without inducing fat pad atrophy.


Regulation (effective) of type in foot
11) Confidence 0.44 Published 2010 Journal J Rehabil Med Section Body Doc Link 20140409 Disease Relevance 0.05 Pain Relevance 0
The authors investigated the effects of the intravenous anesthetics, thiopental and ketamine, and the local anesthetics, lidocaine and bupivacaine, on the activity of glutamate transporter type 2, EAAT2.
Spec (investigated) Regulation (effects) of type associated with glutamate, ketamine, lidocaine and local anesthetic
12) Confidence 0.44 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 13679253 Disease Relevance 0 Pain Relevance 0.74
It has been suggested that serotonin (5-hydroxytryptamine) type-4 (5-HT4) receptors modulate the sensitivity of intrinsic afferents of the intestinal mucosa.
Regulation (modulate) of type associated with serotonin
13) Confidence 0.44 Published 2002 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12061906 Disease Relevance 0 Pain Relevance 0.16
N-methyl-D-aspartate receptor dependent transcriptional regulation of two calcium/calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex.
Regulation (regulation) of type in cerebral cortex associated with nmda receptor and cerebral cortex
14) Confidence 0.44 Published 2003 Journal Neuroscience Section Title Doc Link 14614906 Disease Relevance 0.30 Pain Relevance 0.16
This prospective, randomized, double-blind controlled study was conducted to compare the efficacies of botulinum toxin type A (BoNT-A) and triamcinolone acetonide (TA) on hemiplegic shoulder pain and their effects on arm function in patients with stroke.
Regulation (efficacies) of type in shoulder associated with stroke, shoulder pain and botox
15) Confidence 0.44 Published 2008 Journal Stroke Section Abstract Doc Link 18048857 Disease Relevance 0.54 Pain Relevance 0.41
IMPLICATIONS: Isoflurane enhances desensitized gamma-aminobutyric acid type A receptor (GABA(A)-R) currents, an effect that is subunit-dependent and attenuated by a mutation in an alpha(1)-subunit pore residue of the GABA(A)-R.
Regulation (subunit-dependent) of type in pore associated with gaba and isoflurane
16) Confidence 0.44 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15105205 Disease Relevance 0 Pain Relevance 0.86
Novel treatment of first bite syndrome using botulinum toxin type A.
Regulation (using) of type associated with pain, syndrome, bites and stings and botox
17) Confidence 0.44 Published 2009 Journal Head Neck Section Title Doc Link 19340864 Disease Relevance 0.59 Pain Relevance 0.39
OBJECTIVES: To assess the effects of botulinum toxin type A in the management of benign bilateral masseter hypertrophy.
Regulation (effects) of type in masseter
18) Confidence 0.44 Published 2009 Journal Cochrane Database Syst Rev Section Body Doc Link 19160335 Disease Relevance 0.19 Pain Relevance 0
Menthol and related compounds were investigated for modulation of recombinant human gamma-aminobutyric acid type A (GABA(A), alpha(1)beta(2)gamma(2s)) receptor currents expressed in Xenopus oocytes.
Spec (investigated) Regulation (modulation) of type in oocytes associated with gaba
19) Confidence 0.44 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18593637 Disease Relevance 0 Pain Relevance 0.20
To determine the effectiveness of botulinum toxin type A to reduce pain of recurrent aphthous ulcer, a single blinded placebo controlled trial of botulinum toxin A injection was performed.
Spec (determine) Regulation (effectiveness) of type associated with pain, canker sores and botox
20) Confidence 0.44 Published 2009 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 18584189 Disease Relevance 0.61 Pain Relevance 0.55

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