INT122101

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.36
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap2) endoplasmic reticulum (Tap2) ATPase activity (Tap2)
plasma membrane (Tap2) nucleus (Tap2) protein complex assembly (Tap2)
Anatomy Link Frequency
spike 1
Tap2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 99.60 Very High Very High Very High
antagonist 27 93.76 High High
gABA 1 81.76 Quite High
nerve block 2 80.68 Quite High
Neuropeptide 6 75.00 Quite High
depression 1 75.00 Quite High
agonist 37 67.08 Quite High
tolerance 32 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
qutenza 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 38 79.72 Quite High
Depression 1 75.00 Quite High
Viral Infection 10 63.52 Quite High
Impaired Glucose Tolerance 32 5.00 Very Low Very Low Very Low
Pox Virus Infection 30 5.00 Very Low Very Low Very Low
Sprains And Strains 16 5.00 Very Low Very Low Very Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 8 5.00 Very Low Very Low Very Low
Weight Loss 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BIBP3226 increased spontaneous spike frequency, suggesting an ongoing Y1 receptor-mediated NPY inhibition.
Negative_regulation (inhibition) of Y1 in spike
1) Confidence 0.25 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15470140 Disease Relevance 0.07 Pain Relevance 0.41
Expression of TAP1 alone has been shown to stabilize TAP2 protein and TAP2 mRNA in TAP-deficient cells and could explain the effectiveness of TAP1 alone [30].
Negative_regulation (stabilize) of TAP2
2) Confidence 0.23 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.14 Pain Relevance 0
Expression of TAP1 alone has been shown to stabilize TAP2 protein and TAP2 mRNA in TAP-deficient cells and could explain the effectiveness of TAP1 alone [30].
Negative_regulation (stabilize) of TAP2 mRNA
3) Confidence 0.23 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.14 Pain Relevance 0
Only when the Y1 and Y2 receptors were blocked was the small GLP-1 secretory (presumably G?
Negative_regulation (blocked) of Y1
4) Confidence 0.06 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.23
Endogenous GLP-1 (and GLP-2) meanwhile exert minor exendin(9-39)-sensitive electrogenic responses that are only observed when Y1 and Y2 receptors are blocked.


Negative_regulation (blocked) of Y1
5) Confidence 0.03 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.18

General Comments

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