INT122103

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.05
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) Golgi apparatus (Cdh1) plasma membrane (Cdh1)
cytoplasm (Cdh1)
Anatomy Link Frequency
synapses 1
adenohypophysis 1
Cdh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 4 99.60 Very High Very High Very High
Hyperalgesia 2 98.24 Very High Very High Very High
Neuropathic pain 2 95.24 Very High Very High Very High
Sciatic nerve 2 93.76 High High
Abeta 2 86.48 High High
c fibre 4 81.60 Quite High
Spinal cord 4 75.00 Quite High
Pain 3 61.04 Quite High
imagery 2 29.44 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ureteral Obstruction 25 99.74 Very High Very High Very High
Hyperalgesia 2 98.24 Very High Very High Very High
Neuropathic Pain 2 95.24 Very High Very High Very High
Adhesions 34 89.72 High High
Fibrosis 20 85.64 High High
Stress 12 82.96 Quite High
Injury 12 81.92 Quite High
Sprains And Strains 8 81.12 Quite High
Nociception 2 73.76 Quite High
Coronary Artery Disease 18 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of E-cadherin thus occurs before the onset of mechanical hyperalgesia (approximately 10-21 d postlesion), as reported previously.
Negative_regulation (loss) of E-cadherin associated with hyperalgesia
1) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15470146 Disease Relevance 0.46 Pain Relevance 0.61
Within the first 7 d after axotomy, E-cadherin is rapidly and completely lost from the dorsal horn synapses with which it is affiliated, whereas N-cadherin localization and levels are unchanged; such patterns persist through 28 d postlesion.
Negative_regulation (lost) of E-cadherin in synapses associated with dorsal horn
2) Confidence 0.36 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15470146 Disease Relevance 0.51 Pain Relevance 0.58
Recent studies of the developing rat adenohypophysis found that primordial cells co-expressed E- and N-cadherins, but that hormone-producing cells lost E-cadherin and ultimately possessed only N-cadherin.
Negative_regulation (lost) of E-cadherin in adenohypophysis
3) Confidence 0.28 Published 2010 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2875860 Disease Relevance 0.22 Pain Relevance 0
UUO resulted in downregulation of E-cadherin (no basolateral staining) and greater brown interstitial staining for ?
Negative_regulation (downregulation) of E-cadherin associated with ureteral obstruction
4) Confidence 0.13 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.78 Pain Relevance 0
E-cadherin was blocked with mouse mAb anti-E-cadherin antibody (rr1) [48,49], and gp135 was blocked with mouse mAb anti-gp135 (clone 3F2/DB) [50].
Negative_regulation (blocked) of E-cadherin
5) Confidence 0.07 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1354196 Disease Relevance 0.08 Pain Relevance 0

General Comments

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