INT122117

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 11.30
Pain Relevance 12.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
dorsal horn 4
paw 2
neurons 2
spinal cord 2
cleavage 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 522 100.00 Very High Very High Very High
Inflammation 191 100.00 Very High Very High Very High
Dorsal horn 87 100.00 Very High Very High Very High
Neuropathic pain 21 100.00 Very High Very High Very High
Spinal cord 314 99.98 Very High Very High Very High
antagonist 58 99.96 Very High Very High Very High
antinociception 3 99.90 Very High Very High Very High
Thermal hyperalgesia 84 99.86 Very High Very High Very High
nMDA receptor antagonist 38 99.56 Very High Very High Very High
Central nervous system 13 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 193 100.00 Very High Very High Very High
Neuropathic Pain 148 100.00 Very High Very High Very High
Nervous System Injury 16 99.92 Very High Very High Very High
Hyperalgesia 177 99.86 Very High Very High Very High
Injury 151 99.76 Very High Very High Very High
Brain Hemorrhage 114 99.52 Very High Very High Very High
Nociception 238 98.40 Very High Very High Very High
Necrosis 4 96.84 Very High Very High Very High
Pain 136 96.76 Very High Very High Very High
Cancer 5 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats.
Negative_regulation (decreased) of Gene_expression (expression) of NR2B in dorsal horn associated with antinociception, analgesic and dorsal horn
1) Confidence 0.59 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19224818 Disease Relevance 0.18 Pain Relevance 0.69
We found that, in addition to a marked suppression of thermal hyperalgesia and mechanical allodynia, intrathecal injection ifenprodil treatment causes a decreased expression of NR2B in the spinal cord.
Negative_regulation (decreased) of Gene_expression (expression) of NR2B in spinal cord
2) Confidence 0.59 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19224818 Disease Relevance 0.07 Pain Relevance 0
However, NR2B expression was depressed by 24 hours following the carrageenan inflammation and did not recover during the 5 day period examined.
Negative_regulation (depressed) of Gene_expression (expression) of NR2B associated with inflammation
3) Confidence 0.54 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.77 Pain Relevance 0.26
Thus, in the sensitized neurons suppression of the NR1 phosphorylation results in reduction of thermal hyperalgesia and a decrease in NR2B expression produces an inhibition of mechanical allodynia.
Negative_regulation (decrease) of Gene_expression (expression) of NR2B in neurons associated with allodynia and thermal hyperalgesia
4) Confidence 0.54 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.65 Pain Relevance 0.90
Wilson's study showed that the increased expression of NR2B in the superficial dorsal horn of animal models of neuropathic pain was attenuated following NMDA receptor antagonist pretreatment [37].
Negative_regulation (attenuated) of Gene_expression (expression) of NR2B in dorsal horn associated with nmda receptor antagonist, neuropathic pain and dorsal horn
5) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.59 Pain Relevance 1.65
In the present study, we demonstrated a reduction of Na+/K+ ATPase and increased expression of NCX1 and NR2B in the penumbra by focal cerebral ischemia.
Negative_regulation (reduction) of Gene_expression (expression) of NR2B associated with brain hemorrhage and ischemia
6) Confidence 0.42 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.33 Pain Relevance 0.48
The results indicate that the use of siRNA targeting the NR2B subunit not only decreased the expression of NR2B mRNA and its associated protein, as demonstrated by real-time PCR and Western blotting, but also abolished formalin-induced pain behaviors in rat model.
Negative_regulation (decreased) of Gene_expression (expression) of NR2B associated with pain
7) Confidence 0.42 Published 2005 Journal Gene Ther. Section Abstract Doc Link 15470478 Disease Relevance 0.34 Pain Relevance 0.62
NR2B protein expression, in contrast, was suppressed by the peripheral inflammation.
Negative_regulation (suppressed) of Gene_expression (expression) of NR2B protein associated with inflammation
8) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.86 Pain Relevance 0.35
The suppression of NR2B expression suggests compensation for the enhanced nociceptive activity.
Negative_regulation (suppression) of Gene_expression (expression) of NR2B associated with nociception
9) Confidence 0.40 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208948 Disease Relevance 0.82 Pain Relevance 0.72
In summary, our data indicate that peripheral inflammation with carrageenan results in a transient increase in serine phosphorylation of spinal cord dorsal horn NR1 subunits and a long lasting decrease in the expression of NR2B.
Negative_regulation (decrease) of Gene_expression (expression) of NR2B in spinal cord dorsal horn associated with inflammation, dorsal horn and spinal cord
10) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.74 Pain Relevance 1.03
However, NR2B expression was depressed by 24 hours following the carrageenan inflammation and did not recover during the 5 day period examined.
Neg (not) Negative_regulation (recover) of Gene_expression (expression) of NR2B associated with inflammation
11) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.80 Pain Relevance 0.27
However, there was a significant decrease in the expression of NR2B that was observed 24 hours following the carrageenan injection (ANOVA, Dunnett's test on raw data, p < 0.05).
Negative_regulation (decrease) of Gene_expression (expression) of NR2B
12) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.43 Pain Relevance 0.57
The expression of NR2B (NMDA receptor) and GluR1 (AMPA receptor) subunits was significantly reduced in the TCDD-exposed F1 generation animals compared to vehicle controls.
Negative_regulation (reduced) of Gene_expression (expression) of NR2B associated with nmda receptor
13) Confidence 0.37 Published 2006 Journal Neurotoxicology Section Abstract Doc Link 16839606 Disease Relevance 0 Pain Relevance 0.21
Intrathecal administration of the soluble Eph-B1 receptor chimera prior to the carrageenan injection significantly reduced the phosphorylation levels of NR2B (Fig. 3).
Negative_regulation (reduced) of Gene_expression (levels) of NR2B associated with b1 receptor and intrathecal
14) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.52 Pain Relevance 0.42
However, spinal cord NR2B expression was depressed by the hind paw inflammation.
Negative_regulation (depressed) of Gene_expression (expression) of NR2B in paw associated with inflammation and spinal cord
15) Confidence 0.35 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208948 Disease Relevance 0.84 Pain Relevance 0.73
Similar inhibitory effects were found with another NR2B-NMDAR antagonist Ro25-6981 (Figure 1D and 1E: For 0.3 ?
Negative_regulation (effects) of Gene_expression (found) of NR2B-NMDAR associated with antagonist
16) Confidence 0.33 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.49
The expression of NR2A in the penumbra was significantly increased (153±9%, n=4, *P<0.05) whereas the expression of NR2B was significantly decreased (37±2%, n=4, *P<0.05) as compared with sham-operated controls 3 h after focal cerebral ischemia.
Negative_regulation (decreased) of Gene_expression (expression) of NR2B associated with brain hemorrhage and ischemia
17) Confidence 0.31 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC3015038 Disease Relevance 0.50 Pain Relevance 0.40
However, the expression of NR2A and NR2B in the penumbra was reversed 24 h after focal cerebral ischemia (NR2A: 40±7%; NR2B: 120±16%, n=4, *P<0.05).
Negative_regulation (reversed) of Gene_expression (expression) of NR2B associated with brain hemorrhage and ischemia
18) Confidence 0.31 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC3015038 Disease Relevance 0.51 Pain Relevance 0.40
In the mPFC of SNI rats, NR2B expression was down-regulated; however, this effect was reversed with repeated oral DCS.
Negative_regulation (down-regulated) of Gene_expression (expression) of NR2B associated with nervous system injury
19) Confidence 0.29 Published 2007 Journal Pain Section Abstract Doc Link 17449176 Disease Relevance 0.98 Pain Relevance 0.75
UCB treatment produced a significant decrease in the levels of NR1, NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptors through a calpain-mediated proteolytic cleavage mechanism.
Negative_regulation (decrease) of Gene_expression (levels) of NR2B in cleavage
20) Confidence 0.29 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2690688 Disease Relevance 0.91 Pain Relevance 0.46

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