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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.23

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cell differentiation (Prkd1) cytosol (Prkd1) Golgi apparatus (Prkd1)
plasma membrane (Prkd1) nucleus (Prkd1) intracellular (Prkd1)
Anatomy Link Frequency
dorsal root ganglia 1
Prkd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 1 94.26 High High
qutenza 3 90.40 High High
Kinase C 1 43.64 Quite Low
nociceptor 1 40.68 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 94.10 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of this hypothesis, we found the following. 1) Overexpression of PKCmu enhanced the response of rVR1 to capsaicin and low pH, and expression of a dominant negative variant of PKCmu reduced the response of rVR1. 2) Reduction of endogenous PKCmu using antisense oligonucleotides decreased the response of exogenous rVR1 expressed in CHO cells as well as of endogenous rVR1 in dorsal root ganglion neurons. 3) PKCmu localized to the plasma membrane when overexpressed in CHO/rVR1 cells. 4) PKCmu directly bound to rVR1 expressed in CHO cells as well as to endogenous rVR1 in dorsal root ganglia or to an N-terminal fragment of rVR1, indicating a direct interaction between PKCmu and rVR1. 5) PKCmu directly phosphorylated rVR1 or a longer N-terminal fragment (amino acids 1-118) of rVR1 but not a shorter one (amino acids 1-99). 6) Mutation of S116A in rVR1 blocked both the phosphorylation of rVR1 by PKCmu and the enhancement by PKCmu of the rVR1 response to capsaicin.
Phosphorylation (phosphorylated) of PKCmu in dorsal root ganglia associated with ganglion cysts, qutenza and root ganglion neuron
1) Confidence 0.06 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15471852 Disease Relevance 0.09 Pain Relevance 0.23

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