INT122155

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.20

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lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)
Anatomy Link Frequency
pyramidal layer 2
CA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 7 98.04 Very High Very High Very High
Congenital Anomalies 1 75.00 Quite High
Pathologic Processes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were significant decreases in the density of [(3)H]ketanserin binding to the 5-HT(2A) receptor (5-HT(2A)R) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as well as methiothepin-insensitive [(3)H]sumatriptan binding to the 5-HT(1F)R in the CA 1 (p=0.016), stratum radiatum/lacunosum moleculare (p=0.04) and subiculum (p=0.015) from subjects with schizophrenia.
Negative_regulation (decreases) of CA 1 Binding (binding) of in pyramidal layer associated with sumatriptan and schizophrenia
1) Confidence 0.42 Published 2004 Journal Schizophr. Res. Section Abstract Doc Link 15474910 Disease Relevance 0.60 Pain Relevance 0.20

General Comments

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