INT122156

Context Info Confidence 0.47 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.52 Pain Relevance 0.44

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)

Anatomy Link Frequency liver 2 pyramidal layer 2 CA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Sumatriptan 4 100.00 beta blocker 26 63.28 local anesthetic 2 47.28 antagonist 2 45.44 eye pain 8 5.00 headache 8 5.00 agonist 6 5.00 Pain 4 5.00 topical agent 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Schizophrenia 14 96.24 Congenital Anomalies 2 75.00 Cataract 14 68.56 Pressure And Volume Under Development 8 64.92 Ocular Hypertension 338 50.12 Glaucoma 72 50.00 Hypotension 28 5.00 Open-angle Glaucoma 22 5.00 Conjunctivitis 16 5.00 Blindness 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There were significant decreases in the density of [(3)H]ketanserin binding to the 5-HT(2A) receptor (5-HT(2A)R) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as well as methiothepin-insensitive [(3)H]sumatriptan binding to the 5-HT(1F)R in the CA 1 (p=0.016), stratum radiatum/lacunosum moleculare (p=0.04) and subiculum (p=0.015) from subjects with schizophrenia.

CA 1 Binding (binding) of in pyramidal layer associated with sumatriptan and schizophrenia

1) Confidence 0.47 Published 2004 Journal Schizophr. Res. Section Abstract Doc Link 15474910 Disease Relevance 0.57 Pain Relevance 0.19

There were significant decreases in the density of [(3)H]ketanserin binding to the 5-HT(2A) receptor (5-HT(2A)R) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as well as methiothepin-insensitive [(3)H]sumatriptan binding to the 5-HT(1F)R in the CA 1 (p=0.016), stratum radiatum/lacunosum moleculare (p=0.04) and subiculum (p=0.015) from subjects with schizophrenia.

CA 1 Binding (binding) of in pyramidal layer associated with sumatriptan and schizophrenia

2) Confidence 0.35 Published 2004 Journal Schizophr. Res. Section Abstract Doc Link 15474910 Disease Relevance 0.58 Pain Relevance 0.19

Dorzolamide is metabolized slowly by the cytochrome P450 (CYP) 2B1/2, CYP2E1, and CYP3A2 isoenzymes in the liver to a single N-desethyldorzolamide metabolite, which also accumulates in erythrocytes where it binds primarily to carbonic anhydrase isoenzyme I (CA-I).

CA-I Binding (binds) of in liver

3) Confidence 0.24 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 0.18 Pain Relevance 0.03

Dorzolamide is metabolized slowly by the cytochrome P450 (CYP) 2B1/2, CYP2E1, and CYP3A2 isoenzymes in the liver to a single N-desethyldorzolamide metabolite, which also accumulates in erythrocytes where it binds primarily to carbonic anhydrase isoenzyme I (CA-I).

anhydrase isoenzyme I Binding (binds) of in liver

4) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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