INT122156

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)
Anatomy Link Frequency
liver 2
pyramidal layer 2
CA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 4 100.00 Very High Very High Very High
beta blocker 26 63.28 Quite High
local anesthetic 2 47.28 Quite Low
antagonist 2 45.44 Quite Low
eye pain 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
topical agent 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 14 96.24 Very High Very High Very High
Congenital Anomalies 2 75.00 Quite High
Cataract 14 68.56 Quite High
Pressure And Volume Under Development 8 64.92 Quite High
Ocular Hypertension 338 50.12 Quite High
Glaucoma 72 50.00 Quite Low
Hypotension 28 5.00 Very Low Very Low Very Low
Open-angle Glaucoma 22 5.00 Very Low Very Low Very Low
Conjunctivitis 16 5.00 Very Low Very Low Very Low
Blindness 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were significant decreases in the density of [(3)H]ketanserin binding to the 5-HT(2A) receptor (5-HT(2A)R) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as well as methiothepin-insensitive [(3)H]sumatriptan binding to the 5-HT(1F)R in the CA 1 (p=0.016), stratum radiatum/lacunosum moleculare (p=0.04) and subiculum (p=0.015) from subjects with schizophrenia.
CA 1 Binding (binding) of in pyramidal layer associated with sumatriptan and schizophrenia
1) Confidence 0.47 Published 2004 Journal Schizophr. Res. Section Abstract Doc Link 15474910 Disease Relevance 0.57 Pain Relevance 0.19
There were significant decreases in the density of [(3)H]ketanserin binding to the 5-HT(2A) receptor (5-HT(2A)R) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as well as methiothepin-insensitive [(3)H]sumatriptan binding to the 5-HT(1F)R in the CA 1 (p=0.016), stratum radiatum/lacunosum moleculare (p=0.04) and subiculum (p=0.015) from subjects with schizophrenia.
CA 1 Binding (binding) of in pyramidal layer associated with sumatriptan and schizophrenia
2) Confidence 0.35 Published 2004 Journal Schizophr. Res. Section Abstract Doc Link 15474910 Disease Relevance 0.58 Pain Relevance 0.19
Dorzolamide is metabolized slowly by the cytochrome P450 (CYP) 2B1/2, CYP2E1, and CYP3A2 isoenzymes in the liver to a single N-desethyldorzolamide metabolite, which also accumulates in erythrocytes where it binds primarily to carbonic anhydrase isoenzyme I (CA-I).
CA-I Binding (binds) of in liver
3) Confidence 0.24 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 0.18 Pain Relevance 0.03
Dorzolamide is metabolized slowly by the cytochrome P450 (CYP) 2B1/2, CYP2E1, and CYP3A2 isoenzymes in the liver to a single N-desethyldorzolamide metabolite, which also accumulates in erythrocytes where it binds primarily to carbonic anhydrase isoenzyme I (CA-I).
anhydrase isoenzyme I Binding (binds) of in liver
4) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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