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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.06
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNF, TNFRSF1B) plasma membrane (TNF, TNFRSF1B) signal transduction (TNF)
extracellular space (TNF) cell death (TNFRSF1B) intracellular (TNF)
Anatomy Link Frequency
somatic cell 1
TNF (Homo sapiens)
TNFRSF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Inflammation 68 99.46 Very High Very High Very High
Etanercept 56 99.00 Very High Very High Very High
cytokine 43 96.24 Very High Very High Very High
Inflammatory response 6 94.04 High High
rheumatoid arthritis 90 93.08 High High
Infliximab 40 92.96 High High
Adalimumab 93 82.00 Quite High
methotrexate 45 79.68 Quite High
spinal inflammation 71 77.80 Quite High
Disease Link Frequency Relevance Heat
Disease 65 99.92 Very High Very High Very High
INFLAMMATION 63 99.46 Very High Very High Very High
Hypercalcemia 1 98.16 Very High Very High Very High
Breast Cancer 1 97.88 Very High Very High Very High
Cancer 9 95.08 Very High Very High Very High
Uveitis 57 93.80 High High
Necrosis 8 93.16 High High
Rheumatoid Arthritis 92 93.08 High High
Acute-phase Reaction 1 92.56 High High
Lymphatic System Cancer 8 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF interacts with two different receptors, designated TNFR1 and TNFR2, which are differentially expressed on cells and tissues and initiate both distinct and overlapping signal transduction pathways.
TNF Binding (interacts) of TNFR2
1) Confidence 0.44 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18161752 Disease Relevance 0.92 Pain Relevance 0.17
Etanercept is a recombinant human soluble p75 TNF receptor that binds to TNF-alpha and renders it biologically unavailable.
TNF-alpha Binding (binds) of p75 TNF receptor
2) Confidence 0.23 Published 2004 Journal Clin. Cancer Res. Section Abstract Doc Link 15475440 Disease Relevance 0.60 Pain Relevance 0.13
Etanercept is a dimeric fusion protein that joins the human p75 TNF receptor to the FC domain of human IgG1 (Fig. 2a).
TNF Binding (receptor) of p75 associated with etanercept
3) Confidence 0.19 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 1.32 Pain Relevance 0.59
expression: Etanercept, a recombinant fusion protein, combining extracellular human p75 TNF receptors with the Fc domain of a human IgG1, neutralizing TNF-?
TNF Binding (receptors) of p75 associated with etanercept
4) Confidence 0.17 Published 2010 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2991444 Disease Relevance 1.14 Pain Relevance 0.35
This inflammatory pathway is initiated when TNF is cleaved from the cell surface by a specific metalloproteinase and binds to its two receptors, TNFR-55 and TNFR-75, found in both soluble forms and on somatic cell surfaces.
TNF Binding (binds) of TNFR-75 in somatic cell associated with inflammation and metalloproteinase
5) Confidence 0.14 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721344 Disease Relevance 1.12 Pain Relevance 0.89
Both sTNF and tmTNF ligands interact with either of 2 distinct receptors—TNF receptor 1 (TNFR1, p55, CD120a) and TNF receptor 2 (TNFR2, p75, CD120b)—on a wide variety of cell types to mediate their biological functions [2], [3].
tmTNF Binding (interact) of TNF receptor 2
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0.96 Pain Relevance 0.28

General Comments

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