INT122165

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.46
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TNFRSF1B) extracellular region (TNFRSF1B) plasma membrane (TNFRSF1B)
Anatomy Link Frequency
somatic cell 1
TNFRSF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 23 99.98 Very High Very High Very High
metalloproteinase 8 99.90 Very High Very High Very High
cytokine 70 99.68 Very High Very High Very High
Etanercept 74 99.36 Very High Very High Very High
Lasting pain 22 98.36 Very High Very High Very High
Adalimumab 19 98.28 Very High Very High Very High
Inflammation 90 98.00 Very High Very High Very High
antagonist 21 97.76 Very High Very High Very High
Infliximab 39 97.68 Very High Very High Very High
rheumatoid arthritis 133 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 11 99.98 Very High Very High Very High
Cancer 12 99.80 Very High Very High Very High
Disease 65 99.76 Very High Very High Very High
Pain 126 98.36 Very High Very High Very High
INFLAMMATION 101 98.00 Very High Very High Very High
Breast Cancer 1 97.88 Very High Very High Very High
Rheumatoid Arthritis 136 96.72 Very High Very High Very High
Hypercalcemia 2 95.24 Very High Very High Very High
Autoimmune Disease 7 90.12 High High
Acute-phase Reaction 1 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF interacts with two different receptors, designated TNFR1 and TNFR2, which are differentially expressed on cells and tissues and initiate both distinct and overlapping signal transduction pathways.
TNFR2 Binding (interacts) of
1) Confidence 0.28 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18161752 Disease Relevance 0.92 Pain Relevance 0.17
Etanercept is a recombinant human soluble p75 TNF receptor that binds to TNF-alpha and renders it biologically unavailable.
p75 TNF receptor Binding (binds) of
2) Confidence 0.28 Published 2004 Journal Clin. Cancer Res. Section Abstract Doc Link 15475440 Disease Relevance 0.60 Pain Relevance 0.13
These blockers are derived from either a recombinant TNF receptor, TNFRSF1B in the case of Etanercept, or an anti-TNF-?
TNFRSF1B Binding (recombinant) of associated with etanercept
3) Confidence 0.28 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.87 Pain Relevance 0.61
These blockers are derived from either a recombinant TNF receptor, TNFRSF1B in the case of Etanercept, or an anti-TNF-?
TNF receptor Binding (recombinant) of associated with etanercept
4) Confidence 0.28 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.87 Pain Relevance 0.61
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
p75 Binding (binding) of associated with nerve growth factor, lasting pain and antagonist
5) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.10 Pain Relevance 1.42
This inflammatory pathway is initiated when TNF is cleaved from the cell surface by a specific metalloproteinase and binds to its two receptors, TNFR-55 and TNFR-75, found in both soluble forms and on somatic cell surfaces.
TNFR-75 Binding (binds) of in somatic cell associated with inflammation and metalloproteinase
6) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721344 Disease Relevance 1.09 Pain Relevance 0.87
Etanercept is a tumor necrosis factor recombinant fusion protein consisting of two molecules of the tumor necrosis factor p75 receptor, which binds to the cytokine and thus antagonizes its effect.
factor p75 receptor Binding (binds) of associated with necrosis, cancer, etanercept and cytokine
7) Confidence 0.03 Published 2005 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20476983 Disease Relevance 1.18 Pain Relevance 0.52
It consists of two linked dimmers, each with a ligand-binding portion of the higher affinity type 2 TNF receptor (p75).
TNF receptor Binding (binding) of
8) Confidence 0.03 Published 2005 Journal Int. J. Clin. Pract. Section Abstract Doc Link 15707475 Disease Relevance 0.82 Pain Relevance 0.53

General Comments

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