INT122169

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AKR1C3, PPARG) nucleus (AKR1C3, PPARG) nucleoplasm (PPARG)
intracellular (AKR1C3) enzyme binding (PPARG) DNA binding (PPARG)
Anatomy Link Frequency
HL-60 1
AKR1C3 (Homo sapiens)
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 89.68 High High
Disease Link Frequency Relevance Heat
Leukemia 1 99.34 Very High Very High Very High
INFLAMMATION 2 88.24 High High
Cancer 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human myeloid leukemia (HL-60) cells, ligand access to PPARgamma is regulated by AKR1C3, which diverts PGD(2) metabolism away from J-series prostanoids (Desmond et al., 2003).
AKR1C3 Regulation (regulated) of PPARgamma in HL-60 associated with leukemia
1) Confidence 0.45 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15475569 Disease Relevance 0.26 Pain Relevance 0.33

General Comments

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