INT122188

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Ucn2) extracellular region (Crh, Ucn2) response to stress (Crh, Ucn2)
cell proliferation (Ucn2) cytoplasm (Crh)
Crh (Mus musculus)
Ucn2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 3 96.56 Very High Very High Very High
amygdala 8 93.20 High High
medulla 4 92.40 High High
Visceral pain 1 75.00 Quite High
Hippocampus 2 71.60 Quite High
Potency 2 58.64 Quite High
antagonist 1 34.40 Quite Low
Spinal cord 2 25.64 Quite Low
Pain 3 25.00 Low Low
Thalamus 1 23.28 Low Low
Disease Link Frequency Relevance Heat
Stress 32 79.68 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 75.00 Quite High
Targeted Disruption 10 65.52 Quite High
Nociception 1 25.00 Low Low
Diabetes Insipidus 1 17.36 Low Low
Polyuria 1 13.76 Low Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands.
CRF Binding (binds) of Urocortin 1
1) Confidence 0.22 Published 2004 Journal Peptides Section Abstract Doc Link 15476940 Disease Relevance 0.15 Pain Relevance 0.10
In contrast, Ucn2 and Ucn3 cannot form the dimer complex with CRH-BP.
CRH Binding (complex) of Ucn2
2) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.07 Pain Relevance 0.27

General Comments

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