INT122190

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.65
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) extracellular region (Ucn) plasma membrane (Crhr1)
response to stress (Crhr1) signal transducer activity (Crhr1)
Crhr1 (Mus musculus)
Ucn (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 89.28 High High
Hippocampus 2 88.32 High High
amygdala 8 81.56 Quite High
cerebral cortex 3 79.52 Quite High
Visceral pain 1 75.00 Quite High
Potency 2 63.60 Quite High
medulla 4 62.00 Quite High
Dorsal horn 2 44.88 Quite Low
Thalamus 1 40.00 Quite Low
antagonist 1 39.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 40 99.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 75.00 Quite High
Targeted Disruption 10 35.12 Quite Low
Nociception 3 25.00 Low Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRF receptor 1 (CRF1) binds CRF and Ucn1 with similar high affinity, but CRF receptor 2 (CRF2) binds Ucn1 with higher affinity than CRF.
CRF receptor 1 Binding (binds) of Ucn1
1) Confidence 0.49 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.18 Pain Relevance 0.15
CRF receptor 1 (CRF1) binds CRF and Ucn1 with similar high affinity, but CRF receptor 2 (CRF2) binds Ucn1 with higher affinity than CRF.
CRF1 Binding (binds) of Ucn1
2) Confidence 0.38 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.18 Pain Relevance 0.15
Ucn1 have equal affinities for CRHR1 and CRHR2; however, neither Ucn2 nor Ucn3 binds CRHR1.
CRHR1 Binding (binds) of Ucn1
3) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.05 Pain Relevance 0.26
Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands.
CRF1 Binding (binds) of Ucn
4) Confidence 0.04 Published 2004 Journal Peptides Section Abstract Doc Link 15476940 Disease Relevance 0.16 Pain Relevance 0.11

General Comments

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