INT122195

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 10.61
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
fibroblast 2
platelet 2
oviduct 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 111 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Inflammation 125 99.84 Very High Very High Very High
COX-2 inhibitor 23 99.44 Very High Very High Very High
dexamethasone 3 99.18 Very High Very High Very High
carbamazepine 1 98.32 Very High Very High Very High
cINOD 7 96.16 Very High Very High Very High
fluoxetine 3 93.96 High High
cytokine 119 88.88 High High
medulla 1 82.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 245 100.00 Very High Very High Very High
INFLAMMATION 172 99.84 Very High Very High Very High
Ectopic Pregnancy 95 99.84 Very High Very High Very High
Non-small-cell Lung Cancer 18 99.40 Very High Very High Very High
Cirrhosis 25 98.76 Very High Very High Very High
Enteropathy 7 97.76 Very High Very High Very High
Hypertension 42 97.28 Very High Very High Very High
Renal Cancer 33 97.16 Very High Very High Very High
Hypoxia 26 97.00 Very High Very High Very High
Diabetic Foot Ulcer 1 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation with CsA or dexamethasone did not have any consistent significant effect on VEGF secretion or cell metabolism.
Regulation (effect) of Localization (secretion) of VEGF associated with dexamethasone
1) Confidence 0.57 Published 2007 Journal Cell Transplant Section Abstract Doc Link 17658133 Disease Relevance 0.46 Pain Relevance 0.43
Various types of polymeric materials have been used for controlled release of bFGF and VEGF, including alginate hydrogels, PLG microspheres, and porous PLG scaffolds (22,23).
Regulation (controlled) of Localization (release) of VEGF
2) Confidence 0.51 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.10 Pain Relevance 0
In addition, the targets of sunitinib involve vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), platelet-derived growth factor receptors (PDGFR?
Regulation (involve) of Localization (receptors) of vascular endothelial growth factor in platelet
3) Confidence 0.44 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2890518 Disease Relevance 0.63 Pain Relevance 0
Sensitivity to VEGF-binding affinity of VEGFR1 and VEGFR2
Regulation (Sensitivity) of Localization (affinity) of VEGF-binding
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
In contrast to the findings of others, neither indomethacin nor NS398 affected tumor cell secretion of angiogenic factors (VEGF, bFGF, IL-8) at concentrations that produced maximal inhibition of PGE2 production, and higher concentrations increased angiogenic factor production.
Neg (nor) Regulation (affected) of Localization (secretion) of VEGF associated with cancer
5) Confidence 0.35 Published 2004 Journal Cancer Biol. Ther. Section Abstract Doc Link 15477758 Disease Relevance 0.82 Pain Relevance 0.23
The antitumor activity of plitidepsin, similar to that of some approved single agents together with its unique effects on VEGF secretion which have not been described with other agents used for treatment of RCC open the way to future studies evaluating the potential of combining this marine compound with therapies currently available for the treatment of RCC.



Regulation (effects) of Localization (secretion) of VEGF associated with renal cancer
6) Confidence 0.29 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666889 Disease Relevance 0.34 Pain Relevance 0
This includes the release of the nerve growth factor (NGF), VEGF and basic fibroblast growth factor (bFGF) and the modulations of neurotrophic and angiogenic factors gene expression [61].
Regulation (modulations) of Localization (release) of VEGF in fibroblast associated with nerve growth factor
7) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.52 Pain Relevance 0.19
The implantation environment in the oviduct is very different from that of the well-vascularized endometrium, and production and secretion of VEGF may be affected in EP.
Spec (may) Regulation (affected) of Localization (secretion) of VEGF in oviduct associated with ectopic pregnancy
8) Confidence 0.26 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.65 Pain Relevance 0.04
Adjustments to the internalization flows of VEGF could significantly alter the secretion flows of VEGF needed to maintain the same steady-state interstitial VEGF concentrations, and in turn significantly shift the tissue flow balance on Fig. 4, such that interstitial VEGF might acquire acute sensitivity to transport parameters, as well as to depletory ligand-trapping by sVEGFR1, against our current findings.
Regulation (alter) of Localization (secretion) of VEGF
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Observations such as reduced b-FGF and VEGF secretion and MMP-9 regulation reveals that COX-2 inhibitors possess the potential to be exploited in the in vivo model to better understand their benefits as an adjuvant to the currently available chemotherapy for KS.
Regulation (regulation) of Localization (secretion) of VEGF associated with sarcoma, metalloproteinase and cox-2 inhibitor
10) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.98 Pain Relevance 0.33
In contrast, neutralization of VEGF-C did not affect the angiogenic activity of Calu6/?
Neg (not) Regulation (affect) of Localization (neutralization) of VEGF
11) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.80 Pain Relevance 0
As with diesel exhaust particle exposure, we believe that the production of ROS by the ultrafine particle systems is responsible for this decrease in IL-10 and VEGF secretion, but further investigation, is required to determine and clarify this mechanism.
Spec (investigation) Regulation (responsible) of Localization (secretion) of VEGF
12) Confidence 0.07 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.73 Pain Relevance 0.35
Several studies point to a role for MKK signaling in controlling the release of VEGF and other angioproliferative factors from tumor cells in vitro [20], [34], [35], [36], [37], [38].
Regulation (controlling) of Localization (release) of VEGF associated with cancer
13) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.88 Pain Relevance 0.03
Inflammatory cells, through the secretion of stimulatory factors such as VEGF-C and TNF-?
Regulation (through) of Localization (secretion) of VEGF associated with inflammation
14) Confidence 0.04 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 1.99 Pain Relevance 0.33
activity as well as VEGF secretion is tightly regulated by the oxygen-level, and in the well oxygenated state they are rapidly degraded [24].
Regulation (regulated) of Localization (secretion) of VEGF
15) Confidence 0.03 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1797183 Disease Relevance 1.71 Pain Relevance 0

General Comments

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