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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.00
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
articular cartilage 1
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 121 100.00 Very High Very High Very High
chemokine 9 100.00 Very High Very High Very High
rheumatoid arthritis 44 97.32 Very High Very High Very High
Arthritis 98 97.00 Very High Very High Very High
Inflammation 95 93.68 High High
Osteoarthritis 5 90.52 High High
Pain 3 87.96 High High
Glutamate 1 80.16 Quite High
Inflammatory response 6 74.72 Quite High
palliative 1 74.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 100.00 Very High Very High Very High
Stress 1 98.72 Very High Very High Very High
Autoimmune Disease 41 98.00 Very High Very High Very High
Rheumatoid Arthritis 44 97.32 Very High Very High Very High
Arthritis 102 97.00 Very High Very High Very High
Systemic Lupus Erythematosus 119 96.20 Very High Very High Very High
INFLAMMATION 102 93.68 High High
Cancer 15 91.84 High High
Severe Combined Immunodeficiency 3 91.80 High High
Necrosis 10 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results were confirmed by findings of human Th1/Th2 cytokines in plasma of G93A mice treated with different cell doses.
cytokines Binding (findings) of in plasma associated with cytokine
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.42
Cytokines and their interacting functional capabilities play a pivotal role in the development of RA.
Cytokines Binding (interacting) of associated with rheumatoid arthritis and cytokine
2) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.91 Pain Relevance 0.88
Cytokines, growth factors, chemokines, protease inhibitors, kinases, apoptosis, mechanics, and genetics are increasingly recognized to play key roles in the control of the articular cartilage behavior.
Cytokines Binding (recognized) of in articular cartilage associated with chemokine, apoptosis and cytokine
3) Confidence 0.01 Published 2004 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 15480065 Disease Relevance 0.83 Pain Relevance 0.54
However, key cytokines have been recognized.
cytokines Binding (recognized) of associated with cytokine
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2933908 Disease Relevance 0.73 Pain Relevance 0.12
Upon activation of the cell following the binding of cytokines and growth factors or by UV or stress, a signal transduction cascade unravels that leads to the activation of the serine-threonine kinases, IKK1 and IKK2.
cytokines Binding (binding) of associated with stress and cytokine
5) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.46 Pain Relevance 0.23

General Comments

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