INT12228

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Context Info
Confidence 0.65
First Reported 1984
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 44
Total Number 47
Disease Relevance 17.51
Pain Relevance 40.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
spinal cord 10
hippocampus 9
brain 6
trigeminal ganglion 4
spinal trigeminal nucleus 4
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 807 100.00 Very High Very High Very High
Glutamate 186 100.00 Very High Very High Very High
Hippocampus 60 100.00 Very High Very High Very High
GABA receptor 43 100.00 Very High Very High Very High
Dynorphin 30 100.00 Very High Very High Very High
Gabapentin 54 99.98 Very High Very High Very High
Inflammation 43 99.98 Very High Very High Very High
Clonidine 7 99.98 Very High Very High Very High
Pain threshold 11 99.88 Very High Very High Very High
antidepressant 43 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 98 100.00 Very High Very High Very High
Stress 103 99.98 Very High Very High Very High
INFLAMMATION 36 99.98 Very High Very High Very High
Nervous System Injury 73 99.96 Very High Very High Very High
Pain 306 99.88 Very High Very High Very High
Ganglion Cysts 140 99.24 Very High Very High Very High
Hypertension 11 99.00 Very High Very High Very High
Reprotox - General 1 7 98.94 Very High Very High Very High
Neuropathic Pain 69 98.56 Very High Very High Very High
Sprains And Strains 3 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that partial sciatic nerve ligation decreases thermal and mechanical pain withdrawal latencies, and increases baclofen-stimulated [35S]GTPgammaS binding and GABA(B) receptor subunit gene expression in the rat lumbar spinal cord, suggesting that neuropathic pain may be due, in part, to a deficiency in GABAergic transmission.
Spec (partial) Positive_regulation (increases) of Gene_expression (expression) of GABA in spinal cord associated with pain, gaba, gabaergic, neuropathic pain, sciatic nerve, withdrawal and spinal cord
1) Confidence 0.65 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.74 Pain Relevance 1.39
Although formalin-induced hind paw inflammation increases the production of GABA(B1) and GABA(B2) protein in the spinal cord within 24 h, there is no change in receptor function, as measured by the baclofen-stimulated guanosine 5'-O-(3-[(35)S]thiotriphosphate) ([(35)S]GTPgammaS) binding assay.
Positive_regulation (increases) of Gene_expression (production) of GABA in spinal cord associated with gaba, inflammation and spinal cord
2) Confidence 0.58 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649368 Disease Relevance 0.16 Pain Relevance 0.75
The results indicate that an enhancement in the production of hippocampal GABA(B(1a)) subunits may be a component of the response to antidepressants, supporting a possible role for this receptor in the symptoms of depression and the treatment of this condition.
Positive_regulation (enhancement) of Gene_expression (production) of GABA associated with antidepressant, gaba and depression
3) Confidence 0.51 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451391 Disease Relevance 0.09 Pain Relevance 1.12
An increased expression of GABA transporters in the carrageenan-injected spinal trigeminal nucleus could therefore result in a faster removal of GABA from the synaptic cleft of GABAergic axon terminals compared to normal rats.
Positive_regulation (increased) of Gene_expression (expression) of GABA in spinal trigeminal nucleus associated with gaba and gabaergic
4) Confidence 0.49 Published 2001 Journal Pain Section Abstract Doc Link 11323124 Disease Relevance 0 Pain Relevance 0.24
The results indicate that partial sciatic nerve ligation decreases thermal and mechanical pain withdrawal latencies, and increases baclofen-stimulated [35S]GTPgammaS binding and GABA(B) receptor subunit gene expression in the rat lumbar spinal cord, suggesting that neuropathic pain may be due, in part, to a deficiency in GABAergic transmission.
Spec (partial) Positive_regulation (increases) of Gene_expression (expression) of GABA in spinal cord associated with pain, gaba, gabaergic, neuropathic pain, sciatic nerve, withdrawal and spinal cord
5) Confidence 0.47 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.74 Pain Relevance 1.39
Furthermore, intrapallidal infusion of CGS21680 (10 micromol/l) also increased GABA levels in the globus pallidus.
Positive_regulation (increased) of Gene_expression (levels) of GABA in globus pallidus associated with gaba
6) Confidence 0.47 Published 2000 Journal Neuroscience Section Abstract Doc Link 10996458 Disease Relevance 0 Pain Relevance 0.73
Experiments were undertaken to examine whether once daily i.p. administration of either of two antidepressants used for the treatment of neuropathic pain, amitriptyline (10 mg/kg) and fluoxetine (5 mg/kg), to rats for 7 days modifies GABA(B) receptor function and subunit expression in the lumbar spinal cord.
Spec (whether) Positive_regulation (modifies) of Gene_expression (expression) of GABA in spinal cord associated with gaba, antidepressant, neuropathic pain, endep, spinal cord and fluoxetine
7) Confidence 0.43 Published 2006 Journal Brain Res. Section Abstract Doc Link 16368079 Disease Relevance 0.32 Pain Relevance 1.13
On the other hand, it greatly increased the basal release of GABA and more than doubled the GABA content of the slices at the end of the perfusion, indicating a marked enhancement of GABA synthesis.
Positive_regulation (enhancement) of Gene_expression (synthesis) of GABA associated with gaba
8) Confidence 0.41 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2542805 Disease Relevance 0 Pain Relevance 0.75
We find that clonidine stimulates GABA synthesis in the hypothalamus and the pons-medulla in both strains but the GABA turnover rate is significantly slower in SHR.
Positive_regulation (stimulates) of Gene_expression (synthesis) of GABA in medulla associated with medulla, gaba, hypertension, sprains and strains and clonidine
9) Confidence 0.40 Published 1999 Journal Amino Acids Section Abstract Doc Link 10524271 Disease Relevance 1.05 Pain Relevance 1.07
Ethanol generally augmented also the synthesis of GABA, glutamate, and glutamine at sites reactive to the compound.
Positive_regulation (augmented) of Gene_expression (synthesis) of GABA associated with glutamate and gaba
10) Confidence 0.40 Published 1984 Journal Neurochem. Res. Section Abstract Doc Link 6151627 Disease Relevance 0 Pain Relevance 0.61
It was also discovered that repeated daily exposure to a thermal stimulus or immobilization stress increases GABA(B(1a)) expression in the lumbar spinal cord, with no commensurate change in thermal pain threshold or GABA(B) receptor sensitivity.
Positive_regulation (increases) of Gene_expression (expression) of GABA in spinal cord associated with stress, pain threshold, gaba and spinal cord
11) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16368079 Disease Relevance 0.43 Pain Relevance 1.54
The experiments also demonstrate that daily administration (10 mg/kg, i.p.) of amitriptyline, a tricyclic antidepressant used for the treatment of neuropathic pain, for 1 week after surgery prevents the decline in thermal pain threshold, the increase in GABA(B2) gene expression, and development of increased GABA(B) receptor function in spinal cord resulting from nerve damage.
Positive_regulation (increase) of Gene_expression (expression) of GABA in nerve associated with gaba, pain threshold, nervous system injury, neuropathic pain, tricyclic antidepressant, endep and spinal cord
12) Confidence 0.38 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.75 Pain Relevance 1.51
Perfusion of the neostriatum with morphine (100 microM) significantly increased GABA and dynorphin B levels in the ipsilateral substantia nigra, but no effect was observed locally.
Positive_regulation (increased) of Gene_expression (levels) of GABA in substantia nigra associated with gaba, dynorphin, substantia nigra and morphine
13) Confidence 0.36 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 1.93
All of these antidepressants selectively increased the expression of the GABA(B(1a)) subunit in hippocampus, having no consistent effect on the expression of GABA(B(1b)) or GABA(B(2)).
Positive_regulation (increased) of Gene_expression (expression) of GABA in hippocampus associated with gaba, antidepressant and hippocampus
14) Confidence 0.34 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451391 Disease Relevance 0.06 Pain Relevance 1.26
All of these antidepressants selectively increased the expression of the GABA(B(1a)) subunit in hippocampus, having no consistent effect on the expression of GABA(B(1b)) or GABA(B(2)).
Positive_regulation (increased) of Gene_expression (expression) of GABA in hippocampus associated with gaba, antidepressant and hippocampus
15) Confidence 0.34 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451391 Disease Relevance 0.06 Pain Relevance 1.23
Results with human and rat brain NMR spectroscopy indicate that gabapentin increases GABA synthesis.
Positive_regulation (increases) of Gene_expression (synthesis) of GABA in brain associated with gaba and gabapentin
16) Confidence 0.34 Published 1997 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 9686247 Disease Relevance 0.69 Pain Relevance 1.66
An increased expression of GABA transporters in the carrageenan-injected spinal trigeminal nucleus could therefore result in a faster removal of GABA from the synaptic cleft of GABAergic axon terminals compared to normal rats.
Positive_regulation (result) of Gene_expression (expression) of GABA in spinal trigeminal nucleus associated with gaba and gabaergic
17) Confidence 0.33 Published 2001 Journal Pain Section Abstract Doc Link 11323124 Disease Relevance 0 Pain Relevance 0.25
On the other hand, a pro-akinetic dose (1000 microg/kg) of UFP-512 increased pallidal GABA, simultaneously producing a decrease in GABA and an increase in nigral GLU release.
Positive_regulation (increased) of Gene_expression (producing) of GABA associated with glutamate and gaba
18) Confidence 0.32 Published 2009 Journal Neuroscience Section Abstract Doc Link 19729051 Disease Relevance 0.16 Pain Relevance 0.78
STZ rats presented a significant increase of GABA expression in laminae II and III when compared with control animals, while no differences were detected in GAD expression.
Positive_regulation (increase) of Gene_expression (expression) of GABA associated with gaba and generalized anxiety disorder
19) Confidence 0.30 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.70 Pain Relevance 0.63
Neurotensin (0.2 and 0.5 microM) administered locally through the microdialysis probe to the hippocampus produced a long-lasting and concentration-dependent increase in the basal extracellular levels of GABA and ACh but not of glutamate and aspartate.
Positive_regulation (increase) of Gene_expression (levels) of GABA in hippocampus associated with glutamate, gaba and hippocampus
20) Confidence 0.29 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 0.88

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