INT122285

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.95
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cog1) Golgi apparatus (Cog1)
Anatomy Link Frequency
plasma 2
aorta 1
glial cells 1
connective tissue 1
blood cell 1
Cog1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 99.28 Very High Very High Very High
psoriasis 63 95.12 Very High Very High Very High
cytokine 18 88.88 High High
Inflammation 46 88.48 High High
Restless leg syndrome 2 83.40 Quite High
Inflammatory response 3 82.08 Quite High
Inflammatory marker 1 75.00 Quite High
Demyelination 1 74.68 Quite High
visual analogue scale 1 72.72 Quite High
antagonist 2 68.84 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 130 100.00 Very High Very High Very High
Pain 7 99.28 Very High Very High Very High
Increased Venous Pressure Under Development 18 98.88 Very High Very High Very High
Hyperemia 2 96.42 Very High Very High Very High
Psoriasis 106 95.12 Very High Very High Very High
Diabetes Mellitus 30 91.64 High High
Nicotine Addiction 6 91.04 High High
Peripheral Arterial Disease 3 89.24 High High
INFLAMMATION 51 88.48 High High
Stroke 10 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forearm blood flow after reactive hyperemia response (FBF(h) ) or oral nitroglycerine spray to evaluate endothelial-dependent and endothelial-independent vasodilation, respectively, pain-free and maximal walking distance, levels of C-reactive protein, triglycerides, cholesterol, low-density lipoprotein, and high-density lipoprotein-cholesterol in plasma were determined.
Gene_expression (levels) of low-density lipoprotein in plasma associated with pain, hyperemia and increased venous pressure under development
1) Confidence 0.14 Published 2008 Journal Angiology Section Abstract Doc Link 18388031 Disease Relevance 1.00 Pain Relevance 0.38
The production of NO and superoxide anion (O2-) after treatment with LPS and oxidized low-density lipoprotein (OxLDL) was increased in C26:0-enriched rat glial cells [13].
Gene_expression (production) of low-density lipoprotein in glial cells
2) Confidence 0.14 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613382 Disease Relevance 0.95 Pain Relevance 0.33
For patients with medical treatment, plasma levels of hsCRP, homocysteine, low-density lipoprotein, and the ratio of total cholesterol (TC) to high-density lipoprotein cholesterol (HDL-C) were significantly higher in those with cardiovascular events than those without.
Gene_expression (levels) of low-density lipoprotein in plasma
3) Confidence 0.12 Published 2004 Journal Chest Section Body Doc Link 15486359 Disease Relevance 0.35 Pain Relevance 0
The production of ROS can be indirectly assessed by the levels of lipid peroxidation products such as lipid hydroperoxide (LHP), malondialdehyde (MDA), oxidized low-density lipoprotein (ox-LDL), and thiobarbituric acid (TBA) [87].
Gene_expression (oxidized) of low-density lipoprotein
4) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.51 Pain Relevance 0.16
At the cellular and molecular levels, our results are supported by the fact that insulin has demonstrated proliferative effects on cultured vascular smooth muscle cells; it also enhances lipid synthesis and low density lipoprotein binding to these cells as well as connective tissue synthesis in arterial wall (Stout 1992; Bouguerra et al 2001).
Gene_expression (synthesis) of low density lipoprotein in connective tissue
5) Confidence 0.06 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994018 Disease Relevance 1.40 Pain Relevance 0.07
This consequently results in the production of a relatively lower level of low-density lipoprotein cholesterol and the activation of insulin clearance [33].
Gene_expression (production) of low-density lipoprotein
6) Confidence 0.05 Published 2010 Journal Epidemiology and Health Section Body Doc Link PMC2984863 Disease Relevance 0.35 Pain Relevance 0
The CD31+/CD144+ cells also uptake DiI-acetylated low-density lipoprotein, and rapidly formed vascular network-like structures when placed on Matrigel (Figure 2C).
Gene_expression (uptake) of DiI-acetylated low-density lipoprotein
7) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
In each group, samples of celiac vein blood and the aorta were collected after the last exposure for the measurement of endogenous CO and HO-1 activities, as well as the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).
Gene_expression (levels) of low-density lipoprotein in aorta associated with disorder of lipid metabolism
8) Confidence 0.03 Published 2010 Journal Journal of Cardiovascular Disease Research Section Abstract Doc Link PMC2945201 Disease Relevance 0.86 Pain Relevance 0
Baseline laboratory tests included a complete blood cell count, levels of albumin, creatinine, cholesterol, high density lipoprotein, low density lipoprotein, glucose, gamma-glutamyl transferase, uric acid and urea.
Gene_expression (levels) of low density lipoprotein in blood cell
9) Confidence 0.02 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2919539 Disease Relevance 0.11 Pain Relevance 0.04
Although the pharmacology of niacin is not fully understood, the primary effect is inhibition of the synthesis and secretion of hepatic very low-density lipoprotein cholesterol (VLDL-C) which reduces triglycerides and LDL-C (Grundy et al 1981; Knopp et al 1985).
Gene_expression (synthesis) of low-density lipoprotein
10) Confidence 0.02 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.43 Pain Relevance 0

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