INT122290

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.15
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
macrophage 2
plasma 2
articular 2
blood 2
leukocyte 2
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 10 99.64 Very High Very High Very High
Arthritis 14 99.22 Very High Very High Very High
Inflammation 168 98.88 Very High Very High Very High
Infliximab 1 98.56 Very High Very High Very High
cytokine 25 98.36 Very High Very High Very High
Etanercept 1 98.28 Very High Very High Very High
Hyperalgesia 3 97.52 Very High Very High Very High
rheumatoid arthritis 101 96.00 Very High Very High Very High
Pain 5 75.00 Quite High
Dismenorea 2 71.72 Quite High
Disease Link Frequency Relevance Heat
Adhesions 63 100.00 Very High Very High Very High
Knee Osteoarthritis 4 99.84 Very High Very High Very High
Disease 43 99.24 Very High Very High Very High
Arthritis 35 99.22 Very High Very High Very High
Apoptosis 10 99.20 Very High Very High Very High
INFLAMMATION 210 98.88 Very High Very High Very High
Hyperalgesia 3 97.52 Very High Very High Very High
Necrosis 7 97.16 Very High Very High Very High
Osteoarthritis 9 97.08 Very High Very High Very High
Cancer 7 96.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of 6-shogaol on VCAM-1 concentration in the blood of CFA treated rats
Regulation (shogaol) of Gene_expression (concentration) of VCAM-1 in blood
1) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.38 Pain Relevance 0
Tumor necrosis factor-alpha (TNF-alpha) neutralization with etanercept or infliximab treatment after induction of AIA significantly reduced both macrophage infiltration and VCAM-1 expression.
Regulation (infiltration) of Gene_expression (expression) of VCAM-1 in macrophage associated with necrosis, infliximab, cancer, etanercept and arthritis
2) Confidence 0.41 Published 2009 Journal Pain Section Abstract Doc Link 19560272 Disease Relevance 1.52 Pain Relevance 0.91
The results obtained in the present study suggest that KBG does not possess particular anti-inflammatory or immunomodulating effects but that it has a beneficial effect on articular symptoms and a protective effect against endothelial activation through the reduction of VCAM-1, and it may thereby contribute to the prevention of the progression of cardiovascular disorders in RA patients.
Regulation (effect) of Gene_expression (reduction) of VCAM-1 in articular associated with inflammation and rheumatoid arthritis
3) Confidence 0.33 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.00 Pain Relevance 0.25
The relationship of these two variables showed strong positive correlation in which the magnitude of leukocyte infiltration into the synovial cavity was dependent on the concentration of soluble VCAM-1 produced in the blood.
Regulation (dependent) of Gene_expression (produced) of VCAM-1 in cavity
4) Confidence 0.25 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.44 Pain Relevance 0.14
Also, the relationship between these two variables showed a strong positive correlation (r = 0.98, p < 0.0005, df = 10) in which the magnitude of leukocyte infiltration was dependent on the concentration of soluble VCAM-1 produced in the blood.


Regulation (dependent) of Gene_expression (produced) of VCAM-1 in leukocyte
5) Confidence 0.25 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.14 Pain Relevance 0
Finally, the effects of volemic status and RM on mRNA expressions of ICAM-1 and VCAM-1 were determined because these adhesion molecules are involved in the accumulation of neutrophils in the lung tissue, playing a crucial role in the pathogenesis of VILI [39].


Regulation (effects) of Gene_expression (expressions) of VCAM in lung associated with lung injury and adhesions
6) Confidence 0.22 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.29 Pain Relevance 0.03
VCAM-1 is expressed on impaired endothelium and is regulated by various factors such as inflammatory cytokines (29).
Regulation (regulated) of Gene_expression (expressed) of VCAM-1 in endothelium associated with inflammation and cytokine
7) Confidence 0.20 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.35 Pain Relevance 0.64
Effects of different hyaluronic acid products on synovial fluid levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in knee osteoarthritis.
Regulation (Effects) of Gene_expression (levels) of vascular cell adhesion molecule-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
8) Confidence 0.15 Published 2004 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 15487709 Disease Relevance 0.85 Pain Relevance 0.29
METHODS: Plasma thrombomodulin levels and the values of the plasma adhesion molecules VCAM-1 (vascular cell adhesion molecule 1), E-selectin (CD62E), and ICAM-1 (intercellular adhesion molecule 1, CD 54) were measured by ELISA during a 7-day period of treatment with orally-administered iloprost in 14 patients with active rheumatoid arthritis.
Regulation (measured) of Gene_expression (values) of VCAM-1 in plasma
9) Confidence 0.07 Published 2006 Journal Rheumatol. Int. Section Body Doc Link 15700117 Disease Relevance 0.19 Pain Relevance 0

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