INT1223

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 2.05
Pain Relevance 8.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Snai1) cytoplasm (Snai1)
Anatomy Link Frequency
blood 1
nerve 1
heart 1
Snai1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 42 99.82 Very High Very High Very High
narcan 68 99.68 Very High Very High Very High
anesthesia 19 97.88 Very High Very High Very High
opioid receptor 9 97.60 Very High Very High Very High
Morphine 30 96.68 Very High Very High Very High
analgesia 3 96.16 Very High Very High Very High
withdrawal 14 95.84 Very High Very High Very High
Opioid 3 94.48 High High
Dopamine 2 92.04 High High
Serotonin 6 92.00 High High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 8 99.80 Very High Very High Very High
Pressure And Volume Under Development 3 99.30 Very High Very High Very High
Heart Rate Under Development 2 98.64 Very High Very High Very High
Hypertension 9 97.70 Very High Very High Very High
Nociception 3 80.84 Quite High
Depression 3 78.24 Quite High
Sprains And Strains 1 58.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The baroreflex was checked indirectly by relating both the reflex prolongation in heart period (inter-beat-interval: IBI) and the reflex inhibition of SNA to a pharmacologically induced BP rise.
Negative_regulation (inhibition) of SNA in heart
1) Confidence 0.38 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1280788 Disease Relevance 0.07 Pain Relevance 0.04
In contrast, the baroreflex behaved similarly before and after any treatment, i.e. both the reflex prolongation in IBI (1.34 +/- 0.75 vs 1.39 +/- 0.95 ms/mm Hg) and the reflex inhibition of SNA (0.0312 +/- 0.01 vs 0.0555 +/- 0.015 arbitrary units/mm Hg) caused by that pharmacologically induced BP rise were comparable before and after i.c.v.
Negative_regulation (inhibition) of SNA
2) Confidence 0.38 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1280788 Disease Relevance 0.07 Pain Relevance 0.04
A pronounced immediate increase in adrenal SNA occurs in parallel with renal SNA inhibition.
Negative_regulation (inhibition) of SNA
3) Confidence 0.38 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2160005 Disease Relevance 0.14 Pain Relevance 0.51
Within 1-3 sec, renal SNA was markedly inhibited in parallel with hypotension and bradycardia.
Negative_regulation (inhibited) of SNA associated with heart rate under development and pressure volume 2 under development
4) Confidence 0.38 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2160005 Disease Relevance 0.20 Pain Relevance 0.28
However, older SHR appeared to lose their ability to completely inhibit SNA during induced hypertension, whereas in Wistar control rats as old as 52 weeks, elevation of blood pressure to 165.3 +/- 2.3 mm Hg completely suppressed SNA.
Negative_regulation (suppressed) of SNA in blood associated with pressure and volume under development and hypertension
5) Confidence 0.38 Published 1976 Journal Circ. Res. Section Abstract Doc Link 178466 Disease Relevance 0.48 Pain Relevance 0.06
The baroreceptor-mediated inhibition of adrenal SNA was facilitated while that for renal SNA was attenuated.
Negative_regulation (inhibition) of SNA
6) Confidence 0.35 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2187076 Disease Relevance 0 Pain Relevance 0.85
Although renal SNA was inhibited by approximately 50%, adrenal SNA and lumbar SNA increased by approximately 400 and 80%, respectively.
Negative_regulation (inhibited) of SNA
7) Confidence 0.35 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2187076 Disease Relevance 0 Pain Relevance 0.83
Although an acute arterial pressure (AP) elevation induced by intravenous angiotensin II (ANG II) does not inhibit sympathetic nerve activity (SNA) compared to an equivalent AP elevation induced by phenylephrine, there are conflicting reports as to how circulating ANG II affects the baroreflex control of SNA.
Negative_regulation (inhibit) of SNA in nerve
8) Confidence 0.28 Published 2009 Journal J Physiol Sci Section Abstract Doc Link 19688237 Disease Relevance 0 Pain Relevance 0
However, pretreatment with (-)naloxone (2 or 15 mg.kg-1) induced an increase in rSNA at 0.6% halothane, and subsequently the rSNA inhibition was less pronounced at the two higher halothane concentrations compared with control.
Negative_regulation (inhibition) of rSNA associated with narcan and halothane
9) Confidence 0.22 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2913865 Disease Relevance 0.33 Pain Relevance 1.45
Halothane caused an inhibition of rSNA and hypotension and a decrease in HR at the three halothane concentrations.
Negative_regulation (inhibition) of rSNA associated with pressure volume 2 under development and halothane
10) Confidence 0.22 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2913865 Disease Relevance 0.16 Pain Relevance 1.18
This is in contrast to our previous finding of a marked inhibition of rSNA in rats with intact baroreceptors.
Negative_regulation (inhibition) of rSNA
11) Confidence 0.22 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3250217 Disease Relevance 0.08 Pain Relevance 0.32
We conclude that the influence of the baroreceptors is of minor significance for the inhibition of rSNA during naloxone-precipitated abstinence in anaesthetized rats.
Negative_regulation (inhibition) of rSNA associated with narcan
12) Confidence 0.22 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3250217 Disease Relevance 0.09 Pain Relevance 0.54
In the anaesthetized animals, naloxone doses of 0.05-5 mg kg-1 caused a pronounced inhibition of rSNA, reaching a level 61% below pre-naloxone activity.
Negative_regulation (inhibition) of rSNA associated with narcan
13) Confidence 0.22 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3250217 Disease Relevance 0.05 Pain Relevance 0.57
In conscious, intact rats, however, the baroreceptors seem to contribute to rSNA inhibition since no significance decrease of rSNA occurred in baroreceptor-denervated rats in the present study.
Neg (no) Negative_regulation (decrease) of rSNA
14) Confidence 0.22 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3250217 Disease Relevance 0.09 Pain Relevance 0.37
These findings indicate that the halothane-induced inhibition of rSNA might partially result from a stereospecific activation of opioid receptors, whereas halothane analgesia does not seem to be mediated by opioid mechanisms.
Negative_regulation (inhibition) of rSNA associated with opioid receptor, halothane, opioid and analgesia
15) Confidence 0.22 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2913865 Disease Relevance 0.28 Pain Relevance 1.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox