INT122301

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.38
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
neuronal 2
plasma 1
astrocyte 1
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 14 97.44 Very High Very High Very High
antidepressant 9 96.84 Very High Very High Very High
Hippocampus 25 83.00 Quite High
induced neuropathy 2 82.48 Quite High
depression 1 78.88 Quite High
corticosteroid 1 76.28 Quite High
Desipramine 1 73.92 Quite High
fluoxetine 1 70.72 Quite High
sSRI 1 68.56 Quite High
monoamine 1 62.40 Quite High
Disease Link Frequency Relevance Heat
Death 8 99.06 Very High Very High Very High
Pneumococcal Meningitis 21 98.70 Very High Very High Very High
Neurodegenerative Disease 13 98.04 Very High Very High Very High
Drug Induced Neurotoxicity 4 91.92 High High
Disease 33 84.32 Quite High
Psychosis 1 79.84 Quite High
Depression 1 78.88 Quite High
Affective Disorder 1 78.04 Quite High
Infection 60 58.08 Quite High
Apoptosis 20 54.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We accordingly tested the hypothesis that chronic pretreatment of rats (Sprague-Dawley, male) with antidepressants would attenuate dexamethasone-induced neuronal damage as revealed by reductions in the level of neuronal death and in sublethal neuronal damage shown by the increase in the number of MAP-2 immunoreactive neurons.
Positive_regulation (increase) of MAP-2 in neuronal associated with antidepressant, dexamethasone and death
1) Confidence 0.44 Published 2004 Journal Brain Res. Section Abstract Doc Link 15488477 Disease Relevance 0.49 Pain Relevance 0.73
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Positive_regulation (increased) of MAP2
2) Confidence 0.36 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.08
In addition, most of them were positive for MAP2, mature neural cell marker (Figure 1F); O4, oligodendrocyte marker (Figure 1H); or GFAP, astrocyte marker (Figure 1H).


Positive_regulation (positive) of MAP2 in astrocyte
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0
Rats were all killed after 8 weeks to evaluate the levels of neurofilament(NF)-L, NF-M, NF-H, beta-actin, alpha-tubulin, beta-tubulin, tau, MAP2 proteins in plasma using both SDS-PAGE and western blotting.
Positive_regulation (levels) of MAP2 in plasma
4) Confidence 0.17 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.25 Pain Relevance 0.06
This notion is supported by recent studies [22,23,33,63] assessing neurogenesis in the SGZ after experimental PM which show that approximately 70% of the BrdU-labeled cells are positive for the neuronal markers TUC-4, MAP-2 and beta-tubulin.
Positive_regulation (positive) of MAP-2 in neuronal associated with neurodegenerative disease and pneumococcal meningitis
5) Confidence 0.04 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.39 Pain Relevance 0.04

General Comments

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