INT122323

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 36
Total Number 38
Disease Relevance 35.63
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
Notch 6
plasma 2
pancreatic ducts 2
ducts 2
SH-SY5Y 1
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 33 99.76 Very High Very High Very High
imagery 6 98.30 Very High Very High Very High
Neurotransmitter 2 94.52 High High
sodium channel 2 91.04 High High
cytokine 19 88.00 High High
Inflammation 16 86.28 High High
tetrodotoxin 2 84.72 Quite High
Neuritis 2 82.36 Quite High
cINOD 13 79.92 Quite High
Dismenorea 1 76.36 Quite High
Disease Link Frequency Relevance Heat
Renal Cancer 13 99.96 Very High Very High Very High
Renal Disease 11 99.86 Very High Very High Very High
Thyroid Neoplasm 953 99.84 Very High Very High Very High
Cancer 678 99.84 Very High Very High Very High
Pancreatitis 33 99.76 Very High Very High Very High
Breast Cancer 85 99.74 Very High Very High Very High
Enteritis 1 99.54 Very High Very High Very High
Carcinoid 72 99.52 Very High Very High Very High
Coronary Heart Disease 1 99.32 Very High Very High Very High
Non-small-cell Lung Cancer 20 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, Notch1 activation led to a significant reduction in NE markers.
Positive_regulation (activation) of Notch1
1) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.70 Pain Relevance 0.05
The induction of Notch1 in human BON carcinoid cells led to high levels of functional Notch1, as measured by CBF-1 binding studies, resulting in activation of the Notch1 pathway.
Positive_regulation (activation) of Notch1 associated with carcinoid
2) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.69 Pain Relevance 0
The induction of Notch1 in human BON carcinoid cells led to high levels of functional Notch1, as measured by CBF-1 binding studies, resulting in activation of the Notch1 pathway.
Positive_regulation (induction) of Notch1 associated with carcinoid
3) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.64 Pain Relevance 0
In addition, persistent activation of the Notch1 pathway in BON cells led to a notable reduction in cellular proliferation.
Positive_regulation (activation) of Notch1 associated with hyperplasia
4) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.70 Pain Relevance 0.07
We were interested in determining whether activation of the Notch1 signal transduction pathway in carcinoid cells could modulate production of NE markers and hormones.
Positive_regulation (activation) of Notch1 associated with carcinoid
5) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.50 Pain Relevance 0
Most interestingly, activation of the Notch1 pathway caused a significant reduction in 5-hydroxytryptamine, an important bioactive hormone in carcinoid syndrome.
Positive_regulation (activation) of Notch1 associated with carcinoid and syndrome
6) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.71 Pain Relevance 0.06
As evaluated by time lapse digital imaging, dynamic changes in neurite morphology were rapidly reversible and dependent on the activation of the Notch signaling pathway.
Positive_regulation (activation) of Notch in neurite associated with imagery
7) Confidence 0.67 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.45 Pain Relevance 0.17
The Notch ligand Jagged1, but not Jagged2, was increased in all cell lines, whereas the Notch downstream target Deltex was not expressed.
Positive_regulation (increased) of Notch in Notch
8) Confidence 0.65 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.35 Pain Relevance 0.10
The Notch pathway ligands, Jagged/Delta-like and a Notch target, HES-related repressor protein (HERP), were up-regulated in ectatic compared to normal pancreatic ducts, while another target of Notch, hairy/enhancer of split (HES), was down-regulated.
Positive_regulation (up-regulated) of Notch in pancreatic ducts
9) Confidence 0.64 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.17 Pain Relevance 0.60
Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis.
Positive_regulation (activation) of Notch in ducts associated with chronic pancreatitis
10) Confidence 0.64 Published 2008 Journal J. Pathol. Section Title Doc Link 18069660 Disease Relevance 1.22 Pain Relevance 0.55
We also found elevated transcripts of Notch receptors, Notch1 and Notch3 in microdissected ectatic ducts of CP.
Positive_regulation (elevated) of Notch1 in ducts associated with chronic pancreatitis
11) Confidence 0.64 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.23 Pain Relevance 0.61
These changes in the growth and neuroendocrine phenotype of carcinoid cells were associated with activation of the Notch1 signaling cascade.
Positive_regulation (activation) of Notch1 associated with carcinoid
12) Confidence 0.61 Published 2007 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17874277 Disease Relevance 1.05 Pain Relevance 0.07
The Notch pathway ligands, Jagged/Delta-like and a Notch target, HES-related repressor protein (HERP), were up-regulated in ectatic compared to normal pancreatic ducts, while another target of Notch, hairy/enhancer of split (HES), was down-regulated.
Positive_regulation (up-regulated) of Notch in pancreatic ducts
13) Confidence 0.56 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.19 Pain Relevance 0.61
Similar to its developmental role in the GI tract, Notch1 pathway activation led to an increase in hairy enhancer of split 1 (HES-1) protein and a concomitant silencing of human Notch1/HES-1/achaete-scute homolog 1.
Positive_regulation (activation) of Notch1
14) Confidence 0.50 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.69 Pain Relevance 0
Activation of the Notch pathway in the epithelial component of MCNs was evident by the demonstration of overexpression of Jagged1 and the downstream Notch pathway member Hes1.
Positive_regulation (Activation) of Notch in Notch associated with cancer
15) Confidence 0.49 Published 2004 Journal Oncogene Section Abstract Doc Link 15489895 Disease Relevance 0.73 Pain Relevance 0.08
In many types of cancer, including pancreatic, colon, nonsmall cell lung cancer (NSCLC), cervical and renal cell cancer, Notch1 is upregulated; furthermore, it has been suggested that expression of Notch1 signaling prevents cellular differentiation and inhibits apoptosis in these cancer types.
Positive_regulation (upregulated) of Notch1 in lung associated with non-small-cell lung cancer, cancer, renal cancer and apoptosis
16) Confidence 0.47 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.56 Pain Relevance 0
In our studies, SBHA and VPA treatment of MTC tumor cells resulted in dose-dependent induction of the Notch1-intracellular domain, the active form of the protein [36, 37].
Positive_regulation (induction) of Notch1 associated with thyroid neoplasm and cancer
17) Confidence 0.47 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.35 Pain Relevance 0
Until recently, methods for the delivery of activated Notch1 to tumor cells, aside from gene therapy, had been nonexistent.
Positive_regulation (activated) of Notch1 associated with cancer
18) Confidence 0.47 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.85 Pain Relevance 0
Furthermore, with Notch1 activation there was a concomitant decrease in ASCL1 in vitro, a downstream target of Notch1 signaling.
Positive_regulation (activation) of Notch1
19) Confidence 0.47 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.08 Pain Relevance 0
These observations clearly suggest that Notch1 signaling proteins are conserved in MTC cells and support the idea that Notch1 activation may be a potential target to treat patients with MTC tumors.
Positive_regulation (activation) of Notch1 associated with thyroid neoplasm and cancer
20) Confidence 0.47 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.70 Pain Relevance 0

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