INT122327

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.59
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
neurons 1
synapses 1
neural 1
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 61 99.84 Very High Very High Very High
Kinase C 3 99.48 Very High Very High Very High
opioid receptor 14 99.04 Very High Very High Very High
intrathecal 16 98.28 Very High Very High Very High
mu opioid receptor 4 98.12 Very High Very High Very High
Morphine 8 97.58 Very High Very High Very High
agonist 8 94.16 High High
Glutamate receptor 4 89.96 High High
long-term potentiation 6 86.88 High High
tolerance 8 86.08 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 92.64 High High
Body Weight 1 74.20 Quite High
Opiate Addiction 1 61.56 Quite High
Depression 8 59.84 Quite High
Drug Dependence 1 53.12 Quite High
INFLAMMATION 9 52.64 Quite High
Pain 14 49.08 Quite Low
Neuropathic Pain 18 45.36 Quite Low
Hyperalgesia 25 44.80 Quite Low
Nociception 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also describe recent studies that give insights into the regulation of Src itself at glutamatergic synapses.
Regulation (regulation) of Src in synapses
1) Confidence 0.59 Published 2004 Journal Oncogene Section Abstract Doc Link 15489918 Disease Relevance 0 Pain Relevance 0.31
and PKC and enhance NMDA receptors by targeting the Pyk2/Src regulation of NMDA receptors in CA1 neurons [7].
Regulation (regulation) of Src in neurons associated with nmda receptor
2) Confidence 0.34 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.12 Pain Relevance 0.66
For the biochemical and behavioral studies investigating the effect of inhibiting Src family kinases, the rats received a bolus intrathecal injection of 10 ?
Spec (investigating) Regulation (effect) of Src associated with intrathecal
3) Confidence 0.22 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.35 Pain Relevance 0.18
Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands.
Regulation (regulate) of Src associated with opioid receptor
4) Confidence 0.10 Published 2005 Journal J. Biol. Chem. Section Title Doc Link 15632168 Disease Relevance 0 Pain Relevance 0.33
Thus, in neural cells the Galphaz subunits exert a negative control on Src function reducing the activating influence of MORs on this tyrosine kinase.
Regulation (control) of Src in neural associated with mu opioid receptor
5) Confidence 0.07 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19446022 Disease Relevance 0 Pain Relevance 0.50
Morphine, which has been previously shown to be unable to desensitize or internalize deltaOR, also behaved as TIPP in failure to utilize Src to regulate deltaOR signaling.
Regulation (utilize) of Src associated with morphine
6) Confidence 0.05 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19014372 Disease Relevance 0 Pain Relevance 0.24
This process involves DOR regulation of MORs, MOR-induced activation of NMDARs (probably via the regulation of Src, recruiting PKC and Galpha subunits) and the NMDAR-mediated activation of CaMKII.
Regulation (regulation) of Src associated with kinase c and opioid receptor
7) Confidence 0.02 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630721 Disease Relevance 0.11 Pain Relevance 1.39

General Comments

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