INT122332

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crygb) cytoplasm (Crygb)
Anatomy Link Frequency
brains 1
Crygb (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 10 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Paracetamol 12 99.42 Very High Very High Very High
adenocard 4 98.96 Very High Very High Very High
Spinal cord 8 98.64 Very High Very High Very High
opioid receptor 1 97.56 Very High Very High Very High
agonist 4 96.92 Very High Very High Very High
Enkephalin 1 95.84 Very High Very High Very High
alcohol 1 88.84 High High
antagonist 5 87.20 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol did not significantly compete for binding to the NOP receptor or to the NBTI-sensitive adenosine transporter, showing that it does not mediate its effect via these sites.
NOP receptor Binding (binding) of associated with adenocard and paracetamol
1) Confidence 0.48 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680259 Disease Relevance 0 Pain Relevance 0.92
Quantitative autoradiography has been used to assess whether [3H]paracetamol (3 microM) binds specifically to any area of the murine brain and spinal cord and to investigate whether paracetamol (1-100 microM) competes for binding to the nociceptin opioid peptide (NOP) receptor or to the nitrobenzylthioinosine (NBTI)-sensitive adenosine transporter in the brains of mice. [3H]paracetamol binding was homogenous and, although there was some indication of specific binding overall, this binding in most individual regions failed to reach statistical significance.
NOP Binding (binding) of in brains associated with adenocard, paracetamol, orphanin, opioid and spinal cord
2) Confidence 0.37 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680259 Disease Relevance 0 Pain Relevance 0.78
Schild-analysis indicated a clearly competitive interaction at the NOP receptor, whereas the peptide did not affect the action of the delta-opioid receptor agonist [D-Ala(2),D-Leu(5)]enkephalin.
NOP receptor Binding (interaction) of associated with orphanin, agonist, enkephalin and opioid receptor
3) Confidence 0.02 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15491792 Disease Relevance 0 Pain Relevance 0.84

General Comments

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