INT122367

Context Info Confidence 0.46 First Reported 2004 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 1.47 Pain Relevance 2.40

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1) signal transducer activity (Tacr1)

Anatomy Link Frequency plasma 2 spinal 2 neurons 2 bladder 2 Tacr1 (Mus musculus)

Pain Link Frequency Relevance Heat substance P 63 99.98 Inflammation 58 99.60 Substantia gelatinosa neuron 1 98.28 Lasting pain 2 97.24 Inflammatory mediators 5 96.80 agonist 11 96.40 Kinase C 3 96.24 Pain 6 95.12 cytokine 2 94.60 Spinal cord 5 94.24

Disease Link Frequency Relevance Heat INFLAMMATION 68 99.60 Pain 8 97.24 Increased Venous Pressure Under Development 1 74.64 Cystitis 30 62.08 Emergencies 2 58.64 Neurogenic Inflammation 2 55.04 Bladder Disease 6 40.00 Abnormal Reflex 6 36.88 Overactive Bladder 14 27.68 Cancer 8 16.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, it was interesting to observe that treatment with E2 for 3 h caused a parallel increase in both Tac1 and Tacr1 mRNAs.

Positive_regulation (caused) of Positive_regulation (increase) of Tacr1

1) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.16 Pain Relevance 0.25

NK1 receptor activation leads to enhancement of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse.

Positive_regulation (enhancement) of Positive_regulation (activation) of NK1 receptor in spinal associated with substantia gelatinosa neuron

2) Confidence 0.45 Published 2004 Journal Pain Section Title Doc Link 15494183 Disease Relevance 0.10 Pain Relevance 0.68

To determine whether activation of NK1R increases the transcriptional activities of NF-kappaB and Nkx-2.5, an EMSA was performed.

Spec (whether) Positive_regulation (increases) of Spec (whether) Positive_regulation (activation) of NK1R

3) Confidence 0.39 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09

SP activation of NK1R [3] induces a sequential activation of signaling pathways leading to the production of pro-inflammatory mediators [10,16,17] and pro-inflammatory cytokines such as macrophage migration inhibitory factor (MIF) that plays a major role in bladder inflammation [18].

Positive_regulation (induces) of Positive_regulation (activation) of NK1R in bladder associated with inflammatory mediators, inflammation, cytokine and substance p

4) Confidence 0.34 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 1.07 Pain Relevance 0.76

This secretion mediated by PAR(1) probably occurred by activation of the receptor on the submucosal secretomotor neurons, resulting mainly in the release of tachykinins and activation of the neurokinin-1 receptor, and partly in the release of ACh and activation of the muscarinic and nicotinic receptors.

Positive_regulation (resulting) of Positive_regulation (activation) of neurokinin-1 receptor in neurons

5) Confidence 0.20 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20413722 Disease Relevance 0 Pain Relevance 0.31

Using cholesterol extraction and replenishment assays we show that activation of NK1 receptor is dependent on the microarchitecture of the plasma membrane: NK1R-mediated signaling was abolished after cholesterol depletion of the receptor-expressing cells with methyl-beta-cyclodextrin.

Positive_regulation (dependent) of Positive_regulation (activation) of NK1 receptor in plasma

6) Confidence 0.13 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15590676 Disease Relevance 0.14 Pain Relevance 0.32

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