INT12237

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Context Info
Confidence 0.60
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 24
Disease Relevance 11.09
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
molecular_function (Lipg)
Anatomy Link Frequency
blood 3
plasma 2
soleus 2
myocardium 1
diaphragm 1
Lipg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 17 99.58 Very High Very High Very High
qutenza 15 99.32 Very High Very High Very High
bradykinin 6 94.32 High High
Chronic pancreatitis 4 93.52 High High
Calcium channel 1 93.32 High High
Pain 40 91.92 High High
anesthesia 10 91.88 High High
headache 48 90.36 High High
antagonist 6 89.24 High High
abdominal pain 6 87.76 High High
Disease Link Frequency Relevance Heat
Toxicity 109 99.70 Very High Very High Very High
Hyperglycemia 38 99.00 Very High Very High Very High
Congenital Anomalies 84 98.72 Very High Very High Very High
Disorder Of Lipid Metabolism 48 97.80 Very High Very High Very High
Obesity 8 97.56 Very High Very High Very High
Death 12 94.68 High High
Pancreatitis 45 94.48 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 94.04 High High
Pressure And Volume Under Development 108 93.64 High High
Arthralgia 30 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also shown that increase in speed of both EDL and soleus was much reduced after denervation [26].
Positive_regulation (increase) of EDL in soleus
1) Confidence 0.60 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.62 Pain Relevance 0
RESULTS: Ischemia followed by 1 h reperfusion led to induction of necrotizing pancreatitis, manifested by morphological signs of pancreatic damage, decrease in pancreatic DNA synthesis and PBF, as well as an increase in plasma amylase and lipase activity and plasma IL-1beta concentration.
Positive_regulation (increase) of lipase in plasma
2) Confidence 0.49 Published 2003 Journal Med. Sci. Monit. Section Body Doc Link 14646970 Disease Relevance 0.13 Pain Relevance 0
Further, an intraduodenal injection of fatty acid (linoleic acid) moderately suppressed ASNA and significantly stimulated GVNA; these results indicate that fat may affect autonomic nerve activity partly through the chemoreception of free fatty acids (FFAs), which are produced during the hydrolysis of fat (corn oil) by a pancreatic lipase, in the intestinal lumen.
Positive_regulation (pancreatic) of lipase in intestinal lumen
3) Confidence 0.43 Published 2010 Journal Neurosci. Res. Section Abstract Doc Link 20362017 Disease Relevance 0 Pain Relevance 0
At 4 days the mass of the EDL increased by about 17%, but the maximum tetanic tension and tension per unit cross-sectional area decreased.
Positive_regulation (increased) of EDL in EDL
4) Confidence 0.41 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7081422 Disease Relevance 0.06 Pain Relevance 0.09
Blood serum concentrations of amylase and lipase as well as tissue inflammatory changes and substance P were also significantly elevated during this same time period.
Positive_regulation (elevated) of lipase in Blood
5) Confidence 0.40 Published 2003 Journal Anesthesiology Section Body Doc Link 12552208 Disease Relevance 0 Pain Relevance 0
RESULTS: CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an anti-inflammatory interleukin 10 (IL-10), (by 400%, 1000%, 700% and 50%, respectively), confirmed by histological examination and accompanied by 40% reduction in pancreatic blood flow.
Positive_regulation (increase) of lipase in blood
6) Confidence 0.24 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.17 Pain Relevance 0
The compound elevated total post heparin plasma lipase and skeletal muscle lipase activities.
Positive_regulation (elevated) of plasma lipase in skeletal muscle
7) Confidence 0.23 Published 1989 Journal Indian J. Exp. Biol. Section Abstract Doc Link 2635151 Disease Relevance 0.10 Pain Relevance 0.41
In both the models, serum amylase and lipase activities were markedly increased.
Positive_regulation (increased) of lipase
8) Confidence 0.23 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16183055 Disease Relevance 0.64 Pain Relevance 0.28
This frequency differs among muscles in terms of how this relates to their natural motor unit firing frequencies during normal behaviors in the intact animal, with faster muscles such as the EDL being activated normally at higher frequencies than slower muscles such as the soleus [34], as well as how it relates to their force-frequency relationships, with 20 Hz causing greater degree of contractile fusion in slower muscles such as the soleus compared with faster muscles such as the EDL.
Positive_regulation (activated) of EDL in muscles
9) Confidence 0.22 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0 Pain Relevance 0.04
Similarly, elevated levels of IL-6 mRNA were detected by 2 h of LPS infusion in both tissues, although of a much larger magnitude, peaking at 176-fold elevation of IL-6 mRNA in the EDL and >1000-fold in the myocardium vs controls, following 2 h and 6 h LPS administration respectively (Fig. 3E).


Positive_regulation (elevation) of EDL in myocardium
10) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.04
For the diaphragm peak power was increased at loads of 20 to 50%, whereas EDL power was increased significantly at loads of 30 to 60%.
Positive_regulation (increased) of EDL in diaphragm
11) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0.20 Pain Relevance 0
The effects of DAP on peak power, however, were more variable among muscles (Figure 3), increasing significantly for the diaphragm (P = 0.017) and EDL (P = 0.001) but not for the soleus (P = 0.35).
Neg (not) Positive_regulation (increasing) of EDL in soleus
12) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0.21 Pain Relevance 0
These data suggest Ca2+ influx is required for ligand-stimulated accumulation of both arachidonate (a product of diglyceride-lipase or phospholipase A2) and diglyceride (a product of phospholipase C).
Positive_regulation (accumulation) of diglyceride-lipase
13) Confidence 0.13 Published 1990 Journal Brain Res. Section Abstract Doc Link 1975211 Disease Relevance 0.15 Pain Relevance 0.43
In humans, a proatherogenic role for HL has been suggested from the inverse correlation between increased hepatic lipase activity and the plasma levels of the antiatherogenic HDL and the positive correlation with small dense proatherogenic LDL [35].
Positive_regulation (increased) of lipase in plasma associated with disorder of lipid metabolism
14) Confidence 0.12 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2847988 Disease Relevance 1.42 Pain Relevance 0
Dietary curcumin, capsaicin, piperine, ginger, fenugreek and asafoetida prominently enhanced pancreatic lipase activity.
Positive_regulation (enhanced) of lipase associated with qutenza
15) Confidence 0.09 Published 2000 Journal Nahrung Section Abstract Doc Link 10702999 Disease Relevance 0 Pain Relevance 0.38
Several blood investigations were performed; serum lipase is elevated at 859 (reference range, RR 25–300 U/L).
Positive_regulation (elevated) of lipase in blood
16) Confidence 0.06 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1988801 Disease Relevance 1.04 Pain Relevance 0.07
CCK octapeptide (CCK-8) dose dependently increased trypsin and lipase output in healthy humans.
Positive_regulation (increased) of lipase associated with cholecystokinin
17) Confidence 0.05 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1636705 Disease Relevance 0 Pain Relevance 0.45
Dietary curcumin, capsaicin, piperine and ginger prominantly enhanced intestinal lipase activity and also the disaccharidases sucrase and maltase.
Positive_regulation (enhanced) of intestinal lipase associated with qutenza
18) Confidence 0.05 Published 1996 Journal Int J Food Sci Nutr Section Abstract Doc Link 8616674 Disease Relevance 0 Pain Relevance 0.19
Of grade 3-4 biochemical abnormalities, elevated ALT occurred in 10% of patients, elevated AST in 5%, elevated lipase in 7%, elevated glucose in 3%, decreased phosphate in 8%, and hypermagnesemia in 12%.
Positive_regulation (elevated) of lipase associated with congenital anomalies
19) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC3000369 Disease Relevance 1.28 Pain Relevance 0.27
Rates of other grade 3-4 biochemical abnormalities were low in both treatment arms, including markers of hepatic toxicity (elevated alanine aminotransferase [ALT] or aspartate aminotransferase [AST] each < 1% vs 1%, elevated total bilirubin 1% vs 0%) and pancreatic toxicity (no grade 3/4 elevations in lipase or amylase, or cases of hyperglycemia were recorded).
Neg (no) Positive_regulation (elevations) of lipase in arms associated with hyperglycemia, toxicity and congenital anomalies
20) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC3000369 Disease Relevance 1.46 Pain Relevance 0.26

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