INT122376

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.18
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
plasma 1
neurons 1
nerve 1
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 188 100.00 Very High Very High Very High
cytokine 63 97.80 Very High Very High Very High
fibrosis 75 96.96 Very High Very High Very High
Brush evoked pain 96 93.28 High High
allodynia 12 93.24 High High
Inflammation 200 92.56 High High
withdrawal 30 85.52 High High
Intracerebroventricular 4 75.00 Quite High
sodium channel 2 68.80 Quite High
Neuropathic pain 24 64.32 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 190 100.00 Very High Very High Very High
Nervous System Injury 116 98.24 Very High Very High Very High
Cystic Fibrosis 71 96.96 Very High Very High Very High
Cancer 136 95.80 Very High Very High Very High
Hypersensitivity 14 94.80 High High
Neuropathic Pain 134 93.28 High High
INFLAMMATION 199 92.56 High High
Disease 67 91.52 High High
Hyperplasia 1 85.32 High High
Necrosis 16 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings are in agreement with the pioneer work of Uozumi et al. reporting that cPLA2?
Localization (reporting) of cPLA2
1) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.55 Pain Relevance 0.18
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Localization (secretory) of cPLA2 associated with allodynia
2) Confidence 0.60 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.24
In murine parturition, arachidonic acid is released from cell membranes by cytosolic phospholipase A2 (cPLA2).
Localization (released) of cPLA2
3) Confidence 0.50 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.26 Pain Relevance 0
In murine parturition, arachidonic acid is released from cell membranes by cytosolic phospholipase A2 (cPLA2).
Localization (released) of cytosolic phospholipase A2
4) Confidence 0.50 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.26 Pain Relevance 0
We have previously shown that cPLA2 is translocated to the plasma membrane mainly in medium- to large-diameter DRG neurons [5], but COX-1 was present around the perinuclear region of small-sized DRG neurons.
Localization (translocated) of cPLA2 in neurons associated with dorsal root ganglion
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.92 Pain Relevance 0.69
This results in downstream activation of cPLA2 and release of the prostaglandin precursor arachadonic acid, a potential substrate for COX-2 now known to be induced as an important element of p53 inhibition by MIF.
Localization (release) of cPLA2
6) Confidence 0.27 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.99 Pain Relevance 0
PGs and LTs are metabolites of arachidonic acid (AA) that is released by cytosolic phospholipase A2?
Localization (released) of cytosolic phospholipase A2
7) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 1.55 Pain Relevance 0.44
We observed DRG neurons that were positive for both p-cPLA2 and LPCAT2 in the injured DRG 7 days after nerve injury (indicated by arrowheads, Fig. 5).
Localization (observed) of cPLA2 in nerve associated with dorsal root ganglion and nervous system injury
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.46 Pain Relevance 0.84
bodies, and are released by cytosolic phospholipase A2 (cPLA2) [13]. ?
Localization (released) of cPLA2
9) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.13 Pain Relevance 0.07
A critical role for PHOX in FLZ-elicited neuroprotection was further supported by the findings that 1) FLZ's protective effect was reduced in cultures from PHOX-/- mice, and 2) FLZ inhibited LPS-induced translocation of the cytosolic subunit of p47PHOX to the membrane and thus inhibited the activation of PHOX.
Localization (translocation) of cytosolic
10) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2413210 Disease Relevance 0.78 Pain Relevance 0.11
It has been reported that activation of PHOX holoenzyme is required to initiate the translocation of its cytosolic components p47phox into the plasma membrane [23].
Localization (translocation) of cytosolic in plasma
11) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.06 Pain Relevance 0
O2- production is, most likely, the result of a conformational change in gp91phox, consequent to the translocation of cytosolic components to the membrane environment, and the interaction of one or more components with cytochrome b559, a process termed oxidase assembly [35,36].
Localization (translocation) of cytosolic
12) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.05 Pain Relevance 0

General Comments

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