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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.07
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid metabolic process (Pla2g6) cytoplasm (Pla2g6)
Anatomy Link Frequency
monocytes 1
platelet 1
Pla2g6 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 99.96 Very High Very High Very High
allodynia 4 95.56 Very High Very High Very High
withdrawal 32 94.44 High High
COX2 1 91.96 High High
cOX1 2 91.76 High High
Pain 32 91.20 High High
Eae 3 87.44 High High
Spinal sensitization 2 86.72 High High
addiction 1 84.44 Quite High
Intracerebroventricular 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 15 95.56 Very High Very High Very High
Nociception 12 92.96 High High
Pain 31 91.20 High High
Inflammatory Pain 1 87.44 High High
Hypersensitivity 61 82.04 Quite High
Injury 10 67.12 Quite High
Apoptosis 16 55.92 Quite High
Bordatella Infection 2 40.32 Quite Low
Hyperplasia 2 32.80 Quite Low
Sprains And Strains 59 25.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Localization (secretory) of iPLA2 associated with allodynia
1) Confidence 0.61 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.24
Prior administration of the selective iPLA2 inhibitor BEL (30-300 ?
Localization (administration) of iPLA2
2) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.22 Pain Relevance 0.12
This enzyme family is comprised of approximately 15 groups and four main types, including the secreted sPLA2, cytosolic cPLA2, calcium-independent iPLA2, and platelet activating factor (PAF) [33].
Localization (secreted) of iPLA2 in platelet
3) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.67 Pain Relevance 0.59
generates arachidonic acid in the cytoplasm and localizes to the trailing edge in monocytes migrating towards MCP-1 chemokine, iPLA2 produces LPA and is localized to the pseudopods where actin polymerization is actively regulated.
Localization (localized) of iPLA2 in monocytes associated with chemokine
4) Confidence 0.16 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.05

General Comments

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