INT122378

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.02
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid metabolic process (Pla2g6) cytoplasm (Pla2g6)
Anatomy Link Frequency
monocyte 1
nerve 1
bladder 1
Pla2g6 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2 99.68 Very High Very High Very High
substance P 25 99.38 Very High Very High Very High
Pain 49 99.04 Very High Very High Very High
agonist 48 98.76 Very High Very High Very High
allodynia 24 95.56 Very High Very High Very High
Neuropathic pain 65 94.72 High High
cytokine 5 93.92 High High
intrathecal 5 89.60 High High
Sciatic nerve 12 84.96 Quite High
dorsal root ganglion 12 83.68 Quite High
Disease Link Frequency Relevance Heat
Pain 54 99.04 Very High Very High Very High
Injury 35 98.96 Very High Very High Very High
Nervous System Injury 35 96.88 Very High Very High Very High
Hypersensitivity 120 96.12 Very High Very High Very High
Neuropathic Pain 96 95.56 Very High Very High Very High
Ganglion Cysts 16 83.68 Quite High
Demyelinating Disease 35 71.52 Quite High
INFLAMMATION 68 70.56 Quite High
Cancer 35 68.88 Quite High
Infection 9 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Positive_regulation (calcium-independent) of iPLA2 associated with allodynia
1) Confidence 0.41 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.24
Our results confirmed upregulation of iPLA2 protein in the bladder mucosa of mice instilled with PAR-APs, supporting the upregulation of message levels.
Positive_regulation (upregulation) of iPLA2 protein in bladder
2) Confidence 0.34 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.43 Pain Relevance 0.13
These results suggest that icilin activation of TRPM8 requires a product of iPLA2 activity perhaps acting as a cofactor that enables activation by icilin.
Positive_regulation (requires) of iPLA2
3) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.23 Pain Relevance 0.05
On the other hand, the activities of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2 (iPLA2) were enhanced, with peaks at 1 h after injury.
Positive_regulation (enhanced) of calcium-independent phospholipase A2 associated with injury
4) Confidence 0.28 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20123931 Disease Relevance 1.19 Pain Relevance 0.60
Therefore, intense pain-signals after nerve-injury may induce an excess release of pain transmitters, SP, and glutamate, which in turn activate both cPLA2 and iPLA2 through different pathways (Fig. 3).
Positive_regulation (activate) of iPLA2 in nerve associated with pain, glutamate, injury and substance p
5) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.85 Pain Relevance 0.75
Lysophosphatidic acid is also produced in a spatially regulated fashion by the Ca2+-independent phospholipase A2 (iPLA2) at the leading edge of the migrating monocyte (Carnevale and Cathcart, 2001; Mishra et al., 2008).
Neg (independent) Positive_regulation (independent) of iPLA2 in monocyte
6) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.05 Pain Relevance 0.04
In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2.
Positive_regulation (activation) of iPLA2
7) Confidence 0.12 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2822744 Disease Relevance 0.10 Pain Relevance 0.05

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