INT122381

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2004
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.11
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) extracellular region (Pnoc) plasma membrane (Oprl1)
signal transducer activity (Oprl1)
Anatomy Link Frequency
spinal cord 4
Pnoc (Mus musculus)
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 20 100.00 Very High Very High Very High
antagonist 20 98.44 Very High Very High Very High
substance P 6 96.60 Very High Very High Very High
Spinal cord 4 95.12 Very High Very High Very High
agonist 2 84.40 Quite High
Pain 2 75.00 Quite High
opioid receptor 2 45.88 Quite Low
intrathecal 2 38.92 Quite Low
Disease Link Frequency Relevance Heat
Nociception 10 94.28 High High
Pain 2 75.00 Quite High
Targeted Disruption 2 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that the activation of the ORL-1 receptor by nociceptin may induce the disinhibition of histaminergic neuron and enhance the release of histamine, which subsequently acts on the H1 receptor located on the SP-containing neurons to produce the spinal cord-mediated nociceptive response.
Spec (may) Positive_regulation (induce) of nociceptin Positive_regulation (activation) of ORL-1 receptor in spinal cord associated with nociception, orphanin, spinal cord and substance p
1) Confidence 0.36 Published 2004 Journal Pain Section Abstract Doc Link 15494198 Disease Relevance 0.55 Pain Relevance 0.98
The present results suggest that the activation of the ORL-1 receptor by nociceptin may induce the disinhibition of histaminergic neuron and enhance the release of histamine, which subsequently acts on the H1 receptor located on the SP-containing neurons to produce the spinal cord-mediated nociceptive response.
Spec (may) Positive_regulation (enhance) of nociceptin Positive_regulation (activation) of ORL-1 receptor in spinal cord associated with nociception, orphanin, spinal cord and substance p
2) Confidence 0.36 Published 2004 Journal Pain Section Abstract Doc Link 15494198 Disease Relevance 0.55 Pain Relevance 0.98

General Comments

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