INT1224

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Context Info
Confidence 0.64
First Reported 1976
Last Reported 2011
Negated 3
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 23.69
Pain Relevance 9.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp6) cytoplasm (Fabp6)
Anatomy Link Frequency
blood 3
Plasma 2
cardiac myocytes 2
sensory neurons 1
aorta 1
Fabp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 33 100.00 Very High Very High Very High
agonist 15 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 99.80 Very High Very High Very High
b2 receptor 4 99.50 Very High Very High Very High
Morphine 7 99.44 Very High Very High Very High
anesthesia 16 99.42 Very High Very High Very High
Eae 13 98.20 Very High Very High Very High
narcan 7 97.64 Very High Very High Very High
Serotonin 6 96.76 Very High Very High Very High
ischemia 66 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 432 100.00 Very High Very High Very High
Diabetes Mellitus 375 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 6 100.00 Very High Very High Very High
Heart Rate Under Development 5 100.00 Very High Very High Very High
Anxiety Disorder 15 99.96 Very High Very High Very High
Stroke 63 99.76 Very High Very High Very High
Sprains And Strains 146 99.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 137 99.30 Very High Very High Very High
Vibrio Infection 2 98.76 Very High Very High Very High
Ganglion Cysts 20 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under chloralose:urethane anesthesia, hindlimb blood flow and pressure, plus diameter changes of gracilis muscle arterioles, were simultaneously measured in the 6- and 9-week Wistar-Kyoto (WKY) and SHR.
Gene_expression (measured) of SHR in gracilis associated with anesthesia
1) Confidence 0.64 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 4034536 Disease Relevance 0.34 Pain Relevance 0.10
In the SHR and in the WKY, but not in the WISTAR, the alpha 2-adrenoceptor agonist clonidine in a narrow low dose-range produced anxiolytic-like effects of similar magnitudes.
Gene_expression (produced) of SHR associated with anxiety disorder, agonist and clonidine
2) Confidence 0.57 Published 1989 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2576131 Disease Relevance 0.79 Pain Relevance 0.34
These effects were much more pronounced in SHR.
Gene_expression (pronounced) of SHR
3) Confidence 0.56 Published 1981 Journal Acta Physiol Pol Section Abstract Doc Link 7348526 Disease Relevance 0.15 Pain Relevance 0.79
No differences were found in this respect among SHR and SHR treated with NO donors.
Neg (No) Gene_expression (found) of SHR
4) Confidence 0.50 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15933791 Disease Relevance 0.30 Pain Relevance 0.14
No differences were found in this respect among SHR and SHR treated with NO donors.
Neg (No) Gene_expression (found) of SHR
5) Confidence 0.50 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15933791 Disease Relevance 0.30 Pain Relevance 0.14
Adolescent SHR/NCrlCrlj also demonstrated conditioned place preference to methamphetamine although in both assays differential strain response was not observed.
Gene_expression (/) of SHR associated with sprains and strains
6) Confidence 0.47 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3016305 Disease Relevance 0.79 Pain Relevance 0
Secondly, our results do not coincide with previous studies (which used locomotor activity as an index to the reinforcing effects of drugs) which demonstrated increased behavioral response of an SHR substrain (SHR/NTac) to amphetamine, methylphenidate and the selective D1 receptor agonist SKF-81297, as compared to Wistar Kyoto rats (WKY/NTac) [29-32].
Gene_expression (response) of SHR substrain associated with eae and agonist
7) Confidence 0.47 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3016305 Disease Relevance 0.40 Pain Relevance 0.22
Adolescent SHR/NCrlCrlj also demonstrated conditioned place preference to methamphetamine although in both assays differential strain response was not observed.
Gene_expression (Adolescent) of SHR associated with sprains and strains
8) Confidence 0.47 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3016305 Disease Relevance 0.79 Pain Relevance 0
Microinjection of the selective alpha 2-agonist guanabenz into the anterior hypothalamic area produced depressor and bradycardic responses in SHR-S and Sprague-Dawley rats, while microinjection of the selective alpha 1-agonist phenylephrine into the anterior hypothalamic area had no effect on either blood pressure or heart rate.
Gene_expression (produced) of SHR in anterior associated with agonist
9) Confidence 0.46 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 2848885 Disease Relevance 0.07 Pain Relevance 0.53
In this study, we conducted SA and CPP tests in an SHR substrain obtained from Charles River, Japan (SHR/NCrlCrlj) (via Orient Bio., Korea), to investigate if it shows stable responding for the stimulant methamphetamine.
Gene_expression (conducted) of SHR substrain
10) Confidence 0.41 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3016305 Disease Relevance 1.06 Pain Relevance 0.32
Interestingly, kidney microsomes, known to contain a high constitutive expression of GT-I, preferentially glucuronidated (R)-naproxen (S/R ratio 0.2).
Gene_expression (expression) of GT-I in kidney
11) Confidence 0.39 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1676627 Disease Relevance 0.06 Pain Relevance 0.07
Secondly, our results do not coincide with previous studies (which used locomotor activity as an index to the reinforcing effects of drugs) which demonstrated increased behavioral response of an SHR substrain (SHR/NTac) to amphetamine, methylphenidate and the selective D1 receptor agonist SKF-81297, as compared to Wistar Kyoto rats (WKY/NTac) [29-32].
Gene_expression (response) of SHR associated with eae and agonist
12) Confidence 0.21 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3016305 Disease Relevance 0.40 Pain Relevance 0.22
Together, these four strains allowed us to examine the structural and functional changes in the aorta in the hypertensive SHR, the most widely used animal model of genetic hypertension, while controlling for the variables of hyperactivity and hyperreactivity that are also expressed in the SHR.
Gene_expression (expressed) of SHR in aorta associated with hypertension, attention deficit hyperactivity disorder and sprains and strains
13) Confidence 0.20 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8958987 Disease Relevance 1.13 Pain Relevance 0.08
Under urethane anesthesia, conjugated estrogens still produced greater pressor responses in SHR, but accompanying increases in sympathetic nerve firings were the same in both WKY and SHR.
Gene_expression (produced) of SHR in nerve associated with anesthesia
14) Confidence 0.20 Published 1982 Journal Jpn. Circ. J. Section Abstract Doc Link 6750175 Disease Relevance 0.17 Pain Relevance 0.10
Morphine (3.0 mg/kg subcutaneously) produced greater hypotension and bradycardia in SHR than in WKY or SD rats.
Gene_expression (produced) of SHR associated with heart rate under development, pressure volume 2 under development, hypertension and morphine
15) Confidence 0.19 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15155331 Disease Relevance 1.88 Pain Relevance 1.16
Clonidine [2.5 micrograms intracisternally (i.c.)] produced rapid hypotension (-36 +/- 2 mm Hg) and bradycardia (-53 +/- 5 beats/min) in SHR that were similar to observations in animals given either naloxone (50 micrograms i.c. or 10 mg/kg i.p.) or appropriate saline control injections.
Gene_expression (produced) of SHR associated with heart rate under development, pressure volume 2 under development, hypertension, narcan and clonidine
16) Confidence 0.19 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2581087 Disease Relevance 0.65 Pain Relevance 0.55
Decreasing mean blood pressure to 50-60 torr produced a significant decrease in CBF but not CMRO2 in both WKY treatment groups and in hypertensive treated SHR, but again in sham treated SHR both CBF ana CMRO2 were significantly decreased.
Gene_expression (produced) of SHR in blood associated with hypertension
17) Confidence 0.16 Published 1982 Journal Stroke Section Abstract Doc Link 7123604 Disease Relevance 0.60 Pain Relevance 0.15
We were unable to detect PHF in the SHR.
Neg (unable) Gene_expression (detect) of SHR
18) Confidence 0.07 Published 1998 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9807667 Disease Relevance 0.46 Pain Relevance 0.05
Basilar artery responsiveness to KCl, serotonin (5-HT), and calcium were significantly increased whereas responses to acetylcholine (ACH), isoproterenol (ISO) and sodium nitroprusside (SNP) were significantly reduced in SHR compared to WKY.
Gene_expression (reduced) of SHR in Basilar artery associated with serotonin
19) Confidence 0.07 Published 1993 Journal Life Sci. Section Abstract Doc Link 8231627 Disease Relevance 0.24 Pain Relevance 0.20
However, older SHR appeared to lose their ability to completely inhibit SNA during induced hypertension, whereas in Wistar control rats as old as 52 weeks, elevation of blood pressure to 165.3 +/- 2.3 mm Hg completely suppressed SNA.
Gene_expression (appeared) of SHR in blood associated with pressure and volume under development and hypertension
20) Confidence 0.05 Published 1976 Journal Circ. Res. Section Abstract Doc Link 178466 Disease Relevance 0.48 Pain Relevance 0.07

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