INT12241

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.39
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
pancreas 4
body 2
PRSS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 17 100.00 Very High Very High Very High
Chronic pancreatitis 246 99.84 Very High Very High Very High
fibrosis 38 98.44 Very High Very High Very High
Inflammatory response 3 85.92 High High
Bile 6 79.96 Quite High
abdominal pain 4 75.08 Quite High
Pain management 3 68.40 Quite High
alcohol 27 53.40 Quite High
tetrodotoxin 1 50.00 Quite Low
antagonist 1 46.08 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 335 99.84 Very High Very High Very High
Cystic Fibrosis 15 98.72 Very High Very High Very High
Autolysis 13 89.20 High High
INFLAMMATION 16 85.92 High High
Disease 28 84.28 Quite High
Pancreatic Cancer 21 82.36 Quite High
Duodenal Obstruction 4 81.16 Quite High
Diabetes Mellitus 10 79.20 Quite High
Vomiting 4 78.24 Quite High
Abdominal Pain 4 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To prevent premature trypsin activation within the pancreas, the body has evolved a series of defensive mechanisms.
Negative_regulation (prevent) of Positive_regulation (activation) of trypsin in body
1) Confidence 0.43 Published 2001 Journal BMC Genet Section Body Doc Link PMC60523 Disease Relevance 0.32 Pain Relevance 0
Other genes, such as the anionic trypsinogen (PRSS2), the serine protease inhibitor, Kazal type 1 (SPINK1) and the cystic fibrosis transmembrane conductance regulator (CFTR) have been found to be associated with chronic pancreatitis (idiopathic and hereditary) as well.
Negative_regulation (inhibitor) of Positive_regulation (anionic) of trypsinogen associated with fibrosis, cystic fibrosis and chronic pancreatitis
2) Confidence 0.42 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1774562 Disease Relevance 1.70 Pain Relevance 1.00
One of the challenges in understanding CP in human subjects is distinguishing trypsin-dependent and trypsin-independent pathways in CP from the central role of trypsin in acute pancreatitis.
Negative_regulation (distinguishing) of Positive_regulation (pathways) of trypsin-independent associated with pancreatitis and chronic pancreatitis
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 1.18 Pain Relevance 0.71
One of the challenges in understanding CP in human subjects is distinguishing trypsin-dependent and trypsin-independent pathways in CP from the central role of trypsin in acute pancreatitis.
Negative_regulation (distinguishing) of Positive_regulation (pathways) of trypsin-dependent associated with pancreatitis and chronic pancreatitis
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 1.18 Pain Relevance 0.71
The biochemical and structural data, taken together with a comprehensive sequence comparison, indicates that the tetra-aspartate sequence in mammalian trypsinogen activation peptides has evolved not only for optimal enteropeptidase recognition in the duodenum but also for efficient inhibition of trypsinogen autoactivation within the pancreas.
Negative_regulation (inhibition) of Positive_regulation (autoactivation) of trypsinogen in pancreas
5) Confidence 0.42 Published 2003 Journal Mol. Biol. Evol. Section Abstract Doc Link 12832630 Disease Relevance 0.13 Pain Relevance 0.07
These may predispose to acute pancreatitis by eliminating one of the fail-safe mechanisms used by the pancreas to eliminate prematurely activated trypsin.
Negative_regulation (eliminate) of Positive_regulation (activated) of trypsin in pancreas associated with pancreatitis
6) Confidence 0.41 Published 1999 Journal Baillieres Best Pract Res Clin Gastroenterol Section Abstract Doc Link 11030605 Disease Relevance 0.88 Pain Relevance 0.27
Atropine inhibited CCK-8 (10 ng.kg-1.h-1)-stimulated trypsin output by 84.0 +/- 7.7% and lipase output by 78.6 +/- 9.2%.
Negative_regulation (inhibited) of Positive_regulation (-stimulated) of trypsin associated with cholecystokinin
7) Confidence 0.06 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1636705 Disease Relevance 0 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox