INT122410

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.42
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) cytoplasm (Nqo1)
Anatomy Link Frequency
liver 2
Nqo1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 28 94.72 High High
Paracetamol 6 86.72 High High
Pain 3 72.16 Quite High
Inflammation 17 41.96 Quite Low
Analgesic 1 37.40 Quite Low
cytokine 5 33.12 Quite Low
Central nervous system 61 28.52 Quite Low
Neuritis 25 5.00 Very Low Very Low Very Low
Multiple sclerosis 16 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 215 100.00 Very High Very High Very High
Injury 4 97.56 Very High Very High Very High
Immunization 6 91.24 High High
Multiple Sclerosis 31 87.68 High High
Pain 2 72.16 Quite High
Targeted Disruption 18 50.08 Quite High
INFLAMMATION 18 41.96 Quite Low
Disease 52 20.60 Low Low
Optic Neuritis 24 5.00 Very Low Very Low Very Low
Autoimmune Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heme oxygenase-1 (Ho-1), NAD(P)H quinone oxidoreductase-1 (Nqo1), organic anion-transporting polypeptides (Oatp1a1, 1a4 and 1b2), sodium/taurocholate-cotransporting polypeptide (Ntcp), and multidrug resistance-associated protein (Mrp 1-6) mRNA levels in liver were determined using the branched DNA signal amplification assay.
Transcription (levels) of Nqo1 in liver
1) Confidence 0.68 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.25
Hepatotoxic doses of APAP and CCl4 increased Ho-1 and Nqo1 mRNA levels by 22- and 2.5-fold, respectively, and reduced Oatp1a1, 1a4, and Ntcp mRNA levels in liver.
Transcription (levels) of Nqo1 in liver
2) Confidence 0.51 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.22
DIM and metabolites were detected in all case samples with the exception of NMOR, which tested negative in all cases.
Neg (exception) Transcription (exception) of NMOR
3) Confidence 0.09 Published 2010 Journal J Anal Toxicol Section Abstract Doc Link 20465864 Disease Relevance 0.07 Pain Relevance 0.07
Approachable questions based on a small animal NMO model
Transcription (model) of NMO associated with neuromyelitis optica
4) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.04 Pain Relevance 0.05

General Comments

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