INT122419

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 4.45
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
Anatomy Link Frequency
liver 6
HEK001 1
skin 1
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 39 100.00 Very High Very High Very High
qutenza 21 98.68 Very High Very High Very High
transdermal 10 88.96 High High
cINOD 5 87.12 High High
dexamethasone 1 52.24 Quite High
Morphine 3 50.00 Quite Low
Bile 5 47.20 Quite Low
Inflammation 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 24 100.00 Very High Very High Very High
Overdose 9 100.00 Very High Very High Very High
Breast Cancer 4 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 4 93.32 High High
Fatty Liver 6 92.96 High High
Injury 8 92.36 High High
Gallstones 2 91.64 High High
INFLAMMATION 2 86.72 High High
Disease 3 85.44 High High
Asthma 1 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.
Transcription (levels) of multi-drug resistance associated protein 1 associated with qutenza
1) Confidence 0.70 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.44
RT-PCR analysis revealed the expression of mRNA of numerous transporters including MRP, OATP, MCT and OCTN family members in hairless mouse skin, human skin and HEK001 cells.
Transcription (expression) of MRP in skin
2) Confidence 0.69 Published 2006 Journal J Control Release Section Abstract Doc Link 16380188 Disease Relevance 0 Pain Relevance 0.34
In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.
Transcription (levels) of MRP1 associated with qutenza
3) Confidence 0.67 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.44
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Transcription (determined) of MRP in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
4) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.91 Pain Relevance 0.44
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Transcription (expression) of MRP in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
5) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.73 Pain Relevance 0.42
Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.
Transcription (expression) of MRP1 associated with qutenza
6) Confidence 0.52 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.31
Compared with normal liver specimens, MRP1 and MRP4 mRNA levels were elevated after APAP overdose and in PBC.
Transcription (levels) of MRP1 in liver associated with biliary liver cirrhosis, paracetamol and overdose
7) Confidence 0.51 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.19 Pain Relevance 0.53
RT-PCR analysis revealed the expression of mRNA of numerous transporters including MRP, OATP, MCT and OCTN family members in hairless mouse skin, human skin and HEK001 cells.
Transcription (expression) of MRP in HEK001
8) Confidence 0.24 Published 2006 Journal J Control Release Section Abstract Doc Link 16380188 Disease Relevance 0 Pain Relevance 0.34
Multidrug resistance proteins, which catalyse the detoxification of xenobiotics and excretion of metabolites, are very often controlled at the transcriptional level by interaction of exogenous compounds or hormones with nuclear receptors.
Transcription (at) of Multidrug resistance
9) Confidence 0.11 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15979871 Disease Relevance 0.37 Pain Relevance 0.11
Changes in the mRNA expression of multidrug resistance-associated protein (MRP)2, MRP3 and UDP-glucuronosyltransferase (UGT)2B1 in the liver were estimated using RT-PCR.
Transcription (expression) of multidrug resistance-associated protein in liver
10) Confidence 0.04 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.09 Pain Relevance 0
In the livers of MCD rats, there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein.
Transcription (mRNA) of multidrug resistance-associated protein in livers associated with breast cancer
11) Confidence 0.04 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.92 Pain Relevance 0.99
Heme oxygenase-1 (Ho-1), NAD(P)H quinone oxidoreductase-1 (Nqo1), organic anion-transporting polypeptides (Oatp1a1, 1a4 and 1b2), sodium/taurocholate-cotransporting polypeptide (Ntcp), and multidrug resistance-associated protein (Mrp 1-6) mRNA levels in liver were determined using the branched DNA signal amplification assay.
Transcription (levels) of multidrug resistance-associated protein in liver
12) Confidence 0.03 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.23

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