INT122424

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkci) endosome (Prkci) plasma membrane (Prkci)
nucleus (Prkci) protein complex (Prkci) kinase activity (Prkci)
Anatomy Link Frequency
ovary 1
Prkci (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 15 98.80 Very High Very High Very High
Morphine 12 98.44 Very High Very High Very High
tolerance 3 98.12 Very High Very High Very High
Opioid 3 96.80 Very High Very High Very High
Kinase C 3 93.20 High High
opioid receptor 12 92.48 High High
agonist 3 89.68 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, PMA-induced, but not DAMGO-induced, HmuOR phosphorylation was partially inhibited by the coexpression of PKCI, suggesting that PKCI exerts a selective regulatory effect on HmuOR signaling.
Gene_expression (coexpression) of PKCI
1) Confidence 0.58 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.97
In addition, behavioral studies revealed that both basal and morphine-induced analgesia were significantly enhanced in the mutant mice that lacked expression of PKCI gene, and these mice developed a greater extent of tolerance to morphine analgesia.
Neg (lacked) Gene_expression (expression) of PKCI gene associated with tolerance, analgesia and morphine
2) Confidence 0.58 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 1.07
The interaction of PKCI with HmuOR was recapitulated in Chinese hamster ovary cells that express the full-length HmuOR and PKCI proteins.
Gene_expression (express) of PKCI in ovary
3) Confidence 0.58 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.53

General Comments

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